Formation damage phenomenon constitutes serious operational and economic problems to the petroleum production. Oil production in certain reservoirs is inadvertently impaired by precipitation and deposition of the high molecular weight components such as paraffin wax. A facile applicability of synergistic effects of thermochemical reaction and ultrasonication to mitigate wax deposition has been presented in this article. Thermochemical heat source has to do with exothermic heat generation from certain chemical reactions. On the other hand, ultrasonication causes cavitation and implosion of bubbles, which is trasimmted as energy in the medium and assit in detaching contaminants from the surface. Series of imbibition experiments were conducted at different ultrasound frequencies (low 28kHz, and high 40kHz), exposure times (20, 40, and 60 mins), and different molarities (M1, M2, and M3) of the thermochemical fluids (TCF), for removing wax deposit from tight Scioto Sandstone core samples. The performance was followed through permeability and porosity tests, as well as Scanning Electron Microscopy with Energy-Dispersive X-ray (SEM-EDX) analyses. Ultimately, the results revealed promising potentials for the proposed technology for efficient paraffin wax removal from a tight rock sample up to 70% within the experimental limits investigated.