Experimental Investigation of Guided Wave Imaging in Thin Soft Media under Various Coupling Conditions

Lee, Wei-Ning; Chang, Enoch Jing-Han; Guo, Yuexin; Wang, Yahua

doi:10.1016/j.ultrasmedbio.2018.07.029

Cited by 8 publications

(2 citation statements)

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“…Note that both the estimated group velocity and the calculated one in the simulation were slightly smaller than the theoretical value, (= 5.5 m s −1 for the vessel wall with 30.101 kPa µ based on ρv 2 = µ, where ρ, v and µ are the density, shear wave group velocity and shear modulus, respectively). The group velocity of the shear wave might be influenced by the interaction among the vessel wall, the surrounding medium and BMF inside the vessel lumens of VMP-I for the experimental setup used in SWI (figure 3(d)) (Lee et al 2018). This phenomenon corroborated the necessary incorporation of FSI into the analysis of shear wave propagation on vessel walls.…”

Section: Discussionsupporting

confidence: 53%

Walled vessel-mimicking phantom for ultrasound imaging using 3D printing with a water-soluble filament: design principle, fluid-structure interaction (FSI) simulation, and experimental validation

2020

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The geometry and stiffness of a vessel are pertinent to blood dynamics and vessel wall mechanical behavior and may alter in diseased conditions. Ultrasound-based ultrafast Doppler (uDoppler) imaging and shear wave imaging (SWI) techniques have been extensively exploited for the assessment of vascular hemodynamics and mechanics. Their performance is conventionally validated on vessel-mimicking phantoms (VMPs) prior to their clinical use. Compared with commercial ones, customized VMPs are favored for research use because of their wider range of material properties, more complex lumen geometries, or wall structures. Fused deposition modeling (FDM) 3D printing technique with plastic filaments is a promising method for making VMPs with a complex vessel lumen. However, it may require a toxic solvent or a long dissolution time currently. In this paper, we present a safe, efficient and geometrically flexible method where FDM 3D printing with a water-soluble polyvinyl alcohol (PVA) filament is exploited to fabricate a walled three-branch VMP (VMP-I). As a key step in fabrication, to avoid dissolution of the PVA-printed vessel core by the solution of the tissue-mimicking material, paraffin wax was used for isolation. Paraffin wax is easy to coat (i.e. without any special equipment), of satisfactory thickness (∼0.1 mm), chemically stable, and easy to remove after fabrication, thus making the proposed method practicable for ultrasound imaging studies. VMP-I was examined by B-mode imaging and power Doppler imaging (PDI) to verify complete dissolution of PVA-printed vessel core in its lumen, confirming good fabrication quality. The flow velocities in VMP-I were estimated by uDoppler imaging with a −0.8% difference, and the shear wave propagation speeds for the same phantom were estimated by SWI with a −6.03% difference when compared with fluid-structure interaction (FSI) simulation results. A wall-less VMP of a scaled and simplified coronary arterial network (VMP-II) was additionally fabricated and examined to test the capability of the proposed method for a complex lumen geometry. The proposed fabrication method for customized VMPs is foreseen to facilitate the development of ultrasound imaging techniques for blood vessels.

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Section: Discussionsupporting

confidence: 53%

Walled vessel-mimicking phantom for ultrasound imaging using 3D printing with a water-soluble filament: design principle, fluid-structure interaction (FSI) simulation, and experimental validation

2020

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“…Since the Young modulus was calculated using the group velocity, and resonance phenomena are observed in amplitude spectra, we assumed that resonances did not affect the Young modulus computation. However, other methods for calculating the Young modulus could have been considered (guided waves, 77 phase velocity, 59 reverberant shear waves 34 ), and an assessment of the potential impact of spectral resonances would need to be conducted.…”

Section: Discussionmentioning

confidence: 99%

Resonance, Velocity, Dispersion, and Attenuation of Ultrasound‐Induced Shear Wave Propagation in Blood Clot In Vitro Models

Bosio,

Destrempes,

Yazdani

et al. 2023

J of Ultrasound Medicine

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ObjectiveImprove the characterization of mechanical properties of blood clots. Parameters derived from shear wave (SW) velocity and SW amplitude spectra were determined for gel phantoms and in vitro blood clots.MethodsHomogeneous phantoms and phantoms with gel or blood clot inclusions of different diameters and mechanical properties were analyzed. SW amplitude spectra were used to observe resonant peaks. Parameters derived from those resonant peaks were related to mimicked blood clot properties. Three regions of interest were tested to analyze where resonances occurred the most. For blood experiments, 20 samples from different pigs were analyzed over time during a 110‐minute coagulation period using the Young modulus, SW frequency dispersion, and SW attenuation.ResultsThe mechanical resonance was manifested by an increase in the number of SW spectral peaks as the inclusion diameter was reduced (P < .001). In blood clot inclusions, the Young modulus increased over time during coagulation (P < .001). Descriptive spectral parameters (frequency peak, bandwidth, and distance between resonant peaks) were linearly correlated with clot elasticity values (P < .001) with R2 = .77 for the frequency peak, .60 for the bandwidth, and .48 for the distance between peaks. The SW dispersion and SW attenuation reflecting the viscous behavior of blood clots decreased over time (P < .001), mainly in the early stage of coagulation (first minutes).ConclusionThe confined soft inclusion configuration favored SW mechanical resonances potentially challenging the computation of spectral‐based parameters, such as the SW attenuation. The impact of resonances can be reduced by properly selecting the region of interest for data analysis.

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Diffuse shear wave spectroscopy for soft tissue viscoelastic characterization

et al. 2021

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Experimental Investigation of Guided Wave Imaging in Thin Soft Media under Various Coupling Conditions

Cited by 8 publications

References 50 publications

Walled vessel-mimicking phantom for ultrasound imaging using 3D printing with a water-soluble filament: design principle, fluid-structure interaction (FSI) simulation, and experimental validation

Walled vessel-mimicking phantom for ultrasound imaging using 3D printing with a water-soluble filament: design principle, fluid-structure interaction (FSI) simulation, and experimental validation

Resonance, Velocity, Dispersion, and Attenuation of Ultrasound‐Induced Shear Wave Propagation in Blood Clot In Vitro Models

Diffuse shear wave spectroscopy for soft tissue viscoelastic characterization

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