A new type of hybrid Nano-fluid (Fe 3 O 4 -MgO/H 2 O) was used. Plain and wavy tubes with turbulent flow were considered. Two-phase models were employed for the numerical simulation. The HTC enhancement appears to be more pronounced at φ = 2% in both tubes. HTC increment is slightly higher with a wavy-walled tube than the plain one. The newest class of heat transfer improvement is accomplished by using hybrid Nano-fluids. Therefore, the heat transfer and pressure drop of a mixture of Iron oxide (Fe 3 O 4 ) and Magnesium oxide (MgO) nanoparticles suspended into the base fluid under a turbulent regime through a plain and wavy tube are computed employing commercial software ANSYS Fluent. A mixture of Fe 3 O 4 and MgO nanoparticles in pure water is considered a brand-new type of hybrid Nano-fluid for boosting heat transfer. The simulation procedures were performed utilizing the single and multiphase (mixture) approaches at Reynolds number in the range of (3,916 -31,331) and volume concentrations range of (0.5% ≤ φ ≤ 2%). The plain and wavy walls are subjected to a constant heat flux of 18,189 W/m 2 , and the flow is presumed as fully developed. The computed outcomes are validated with the correlation equations and experimental data of literature. The outcomes demonstrate that boosting the nanoadditives fraction leads to a remarkable improvement of heat transfer and hydrothermal performance indicator (HPI) of MgO-Fe 3 O 4 /H 2 O Hybrid Nano-fluid through the considered tubes compared with the conventional base fluid. However, the increment is slightly higher with a wavy wall tube than with the plain one. Moreover, new correlations were suggested for specific water-based hybrid Nano-fluid volume concentrations.