Composite materials have attracted researchers in vibration and noise control applications due to their significant dynamic characteristics such as high strength and high damping level. In this paper, a Glass Fiber Reinforced Composite material (GFRC) is presented as a vibration isolation system to control vibration levels in industry. A prototype of an industrial cam–follower machine is motorized, and the Frequency Response Function (FRF) is recorded using a B&K data acquisition analyzer at five rotational speeds. The transmitted vibrations to the machine foundation are estimated without any isolation system. Then, two optimized GFRC plates of optimum stacking sequences are used as an isolation system to reduce the transmitted vibration. The displacement transmissibility is calculated theoretically and experimentally. Furthermore, the isolation system is integrated with a mechatronic system for improving the isolation performance and enhancing the machining process. The results show that the use of GFRC plates as an isolator reduces the vibration level of the system by 98.46% and 98.5% for [90/90/90/0/0]s and [90/±45/±35/90/±35]s GFRC configurations respectively. Finally, this study proposes a novel strategy for isolation and vibration control technique by employing GFRC plates. The proposed mechatronics control system can be utilized for enhancing system performance and increasing the control of vibration levels.