In comparison to single-row cascades, tandem cascades offer the advantages of reduced losses and enhanced operational capabilities, making them widely employed in compressor applications. However, current research on tandem cascades in hydraulic equipment remains relatively limited. In order to explore the potential application of two-dimensional tandem cascade structures in hydrodynamics and investigate their performance differences from single-row cascades, this study proposes a design scheme for a tandem cascade based on an existing single-row cascade design. Numerical simulation technology is utilized to compare and analyze the impact of these two designs on various flow losses under identical working conditions. The results indicate that compared to single-row vanes, the vane configuration of a serial-row design can better reduce losses and increase the pressure difference between the upper and lower surfaces of the vanes, thereby enhancing their load-bearing capacity and stability. This research finding is expected to provide valuable insights for future water pump design and optimization.