Reducing heat leakage is crucial for the development of practical superconducting devices. In this work, orthogonal experimental design method is first used to optimize the design of hundred-ampere and kiloampere Peltier current leads (PCLs). Geometry and arrangement of Peltier materials and conductive materials of the current lead are analyzed. Through our simulation, we find that the coupling effect between the radius of Bi2Te3 (r2) and the length of Bi2Te3 (L2) has the greatest effect on the heat leakage of PCLs at the cold end for both PCLs. Furthermore, numerical simulations suggest that the lowest heat leakage at the cold end (approximately 30.0 W/kA) is at the same level for both hundred-ampere and kiloampere PCLs. If taking the heat dissipation area at the hot end into account, multiterminal solutions are better solutions for kiloampere current leads.