In order to broaden the application of vortex tubes (VOTU) in industry and to improve the efficiency of cooling and heating, numerical simulations of vortex tubes were carried out. In this study, the temperature, velocity, and pressure fields of three VOTUs with inlet nozzles of 2, 3, and 6 were investigated at different inlet pressures based on previous experimental data and by three-dimensional numerical simulation. It was found that the increase of inlet pressure leads to the increase of energy separation between the hot and cold ends of the three VOTUs. As the number of inlets increases, the pressure difference between the tube wall and the core region gradually strengthens. In contrast, the pressure in the tube center is not affected by the inlet pressure. The number of nozzles affects the inlet and outlet temperatures of the VOTU. When the number of nozzles is 3, and the inlet pressure is 0.6 MPa, the VOTU shows the maximum hot and cold outlet temperature difference of 66 K. The maximum velocity of VOTU appears at the connection of the inlet and vortex chamber, so the inlet is tangential to VOTU, which is beneficial to reduce the loss of gas energy. The wall thickness of the inlet increases gradually to avoid the high-speed gas flow on the erosion of the wall surface. This study has profound guidance for the one-dimensional design of VOTUs.