In houses and general buildings of environment where smoke control equipment is not installed, or its operation is difficult, there is a need to develop and utilize a portable smoke exhaust fan that can perform emergency ventilation in case of fire suppression and rescue operations. As a part of the development process for portable smoke exhaust fans, a numerical analysis model of the portable smoke exhaust fan was derived from the building in which a fire occurred, and an analysis on the smoke and toxic gas exhaust effects was performed in this study. The numerical analysis results showed that under a condition where the height of an opening is less than 1.0 m after fire source disappears in a situation where the smoke exhaust fan does not operate, smoke does not come out well, and thus the density of smoke within the target area does not drop significantly. On the other hand, if the smoke exhaust fan operates after the fire source disappears, smoke is directly exhausted to the outside due to the operation of the smoke exhaust fan, and the smoke density within the space drops sharply in all opening height conditions, thereby getting close to zero.