The main objective of this study is to observe the effects of compression ratio (CR) variation on the engine performance and exhaust emission characteristics of a single-cylinder diesel engine fueled by waste fusel oil (F), waste cooking oil biodiesel (BD), and waste tire pyrolysis oil (P). For this purpose, Diesel RK software was used and the analyzes were performed at varying CRs of 18.3, 20.3, and 22.3. Analyzes were carried out at 2400 rpm constant engine speed, and varying engine loads (3, 6, 9, and 12 Nm). In the results, it is noticed that as the CR increased, BSFC (Brake Specific Fuel Consumption) value also increased for all test fuels. However, at low loads (3 and 6 Nm), the BSFC value decreased as the compression ratio increased after CR20.3. While the maximum BSFC value was obtained to be 560.55 g/kWh for P20 fuel at 3 Nm for CR20.3, the minimum one was achieved to be 46.76 g/kWh for neat diesel fuel at 12 Nm for 18.3. As the CR increased, the BTE (Brake thermal efficiency) value decreased for all test fuels at nearly all loads. However, at low loads (3 and 6 Nm), it is observed that the BTE improved as the CR increased after CR20.3. While maximum BTE was calculated to be 32.07% for P10F10 fuel at CR18.3 compression ratio at 12 Nm load, minimum one was achieved to be 15.36% for P20 at 3 Nm load for CR20.3. In addition, the NOx increased at all loads as CR increased for all test fuels. The maximum NOx value for P20 was recorded to be 1300 ppm at 12 Nm load and CR22.3. A minimum NOx was detected as 144. 56 ppm for P10F10 at 3 Nm, and CR18.3. In conclusion, the paper has proved that the experimental results are well-fitting with those of simulation software.