Due to the unique characteristics of sandy soil layers, there is often a coupling effect of multiple grout diffusion patterns in the grouting process, and different slurry diffusion modes may lead to different responses of soil structures. In this study, laboratory grouting model tests were conducted with homogeneous sand under different water-to-cement (w/c) ratios to reveal the temporal variations in grouting pressure, soil stress fields, and displacement fields during the grout diffusion process. The results show that, during the grouting process in the fine sand layer, the grout mainly exhibited a compaction–splitting diffusion mode. The farther away from the grouting center, the more pronounced the hysteresis effect of soil pressure caused by grout diffusion. Meanwhile, as the w/c ratio increased, the diffusion mode between the slurry and the soil was in a transitional state. At w/c > 1.2, the primary pattern changed from the fracture–compaction pattern to the permeation–fracture–compaction pattern and fracture–permeation pattern. And the overall trend of the grouting pressure curve was similar under all of the w/c ratio conditions, showing a trend of increasing to the maximum value of the pressure first and then decreasing. With the increase in the water–cement ratio, the overall value of the grouting pressure curve showed a decreasing trend, the pressure value increased more slowly with time before reaching the maximum value, and the more obvious the influence of water–cement ratio was when w/c > 1.2. Additionally, the surface displacement also exhibited an overall decreasing trend, and it had no obvious lifting value under the condition of w/c = 1.6.