Experimental investigation on the micronization of aqueous cefadroxil by supercritical fluid technology

Solubility of fluvoxamine maleate in supercritical carbon dioxide

“…[ 1 6 5 _ T D $ D I F F ] (7)). Relative standard deviationðRSDÞ ¼ 100 Â standard deviation avearge of solublity at each point (7) As it is obvious in the listed results in Table 3, an increase in the pressure from 200 bar to 400 bar while the temperature held constant leads to an increase in the solubility of fluvoxamine maleate (see Fig. 2).…”

“…One of the most concentered areas for new clean and efficient methods is pharmaceutical engineering and drug delivery industries. Among the different possible and potential processes, supercritical based technologies are the most examined one introduces satisfactory results [1][2][3][4][5][6][7].…”

Supercritical Fluid Technology: A Review

“…The last stage of particle growth is considered as particle conditioning. A more stable and less energic surface of terbutalin sulphate microparticles were obtained due to above phenomenon, which in turn improved powder flow and aerosolization performance.Zhiyi et al[50] prepared microparticles of water soluble drug, cefadroxil, from water-ethanol mix solvent by SAA process. They investigated the influence of operational parameters, including mixing vessel pressure and temperature, solution concentration, and solution feed rate on particle morphology (PM), particle diameter (PD) and particle diameter distribution (PDD).…”