The performance of a twin-screw compressor is influenced by leakages, which are normally calculated using isentropic nozzle equations with flow coefficients. The changes in the clearances during operation necessarily require detailed studies for accurate leakage estimations. In this research, the flow coefficient correlations are derived for various shapes of leakage gaps using previous experimental results and regression analysis. They are integrated into SCORG (Screw Compressor Rotor Grid Generator) software to estimate leakages and performance of an oil-free twinscrew compressor. The results obtained from the proposed flow coefficients are firstly compared with the original inbuilt flow coefficients and experimental results of the same compressor for the designed assembly clearances. The clearances are then adjusted to approximate the operating clearances, and they are used for further investigation of the same compressor profile (different sizes) at various pressure and speed conditions. The findings indicate that the flow of the compressor using the new flow coefficients is greater than the flow estimation using the original flow coefficients, up to ~41%, ~31% and ~24% for three different sizes of compressors, each larger than the previous one. The total power consumption for all models in all sizes and operational circumstances is within 1% of the calculation with original clearances.