Experimental Investigations on the Penetration into the Eyeball of Iron Administered Intraorbitally

Gerkowicz, K; Prost, M

doi:10.1159/000309369

Cited by 5 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, ions migrate across the vitreous in a posterior-anterior way to the aqueous. Then, they penetrate the deep cornea layers and trabecular meshwork, which allows them to reach the suprachoroidal space and diffuse to the choroid and Bruch's membrane until reaching the retinal pigment epithelium (RPE) posteriorly [27,28].…”

Section: Pathogenesismentioning

confidence: 99%

Ocular siderosis: a misdiagnosed cause of visual loss due to ferrous intraocular foreign bodies—epidemiology, pathogenesis, clinical signs, imaging and available treatment options

et al. 2020

View full text Add to dashboard Cite

Purpose The purpose of this paper is to provide a meaningful literature review about the epidemiology, pathogenesis, clinical signs, imaging and treatment of ocular siderosis (OS). Methods A computerized search from inception up to March 2020 of the online electronic database PubMed was performed using the following search strings: “ocular siderosis” and “siderosis bulbi”. The reference list in each article was analysed for additional relevant publications. Results OS is an uncommon cause of visual loss due to a retained ferrous intraocular foreign body (IOFB). It may develop from 18 days to years after a penetrating trauma that usually occurs during hammering. On average, patients are 22–25 years old, and the vast majority are male. The most common cause of OS development is delayed presentation by the patient or missed diagnosis of IOFB after trauma. The pathophysiology is not fully understood; nevertheless, iron deposition causes hydroxyl radical formation, which damages photoreceptors and retinal pigment epithelium. Moreover, iron damages retinal vessels with consequent inner retinal layers degeneration. The most frequent signs are iris heterochromia, pupillary mydriasis, cataract development and retinal arteriolar narrowing with pigmentary retinal degeneration. Electroretinogram signs, in particular, b-wave amplitude reduction, arise earlier than clinical signs. Orbital CT scans and ultrasonography play an essential role in detecting IOFBs. Treatment depends on the IOFB location and OS development. However, it is crucial to remove the IOFB after OS development because visual acuity and clinical signs may improve. Anterior segment IOFBs can be dislodged using an intraocular magnet (IOM) or forceps through limbal paracentesis. In contrast, posterior segment IOFBs require a pars plana vitrectomy and IOM or forceps to be removed through an enlarged sclerotomy or the limbus. Conclusion Recommending the usage of protective glasses and spreading knowledge about OS may further benefit patient care.

show abstract

Section: Pathogenesismentioning

confidence: 99%

Ocular siderosis: a misdiagnosed cause of visual loss due to ferrous intraocular foreign bodies—epidemiology, pathogenesis, clinical signs, imaging and available treatment options

et al. 2020

View full text Add to dashboard Cite

show abstract

Studies on the use of desferrioxamine in experimental ocular siderosis produced by extrabulbar administration of iron

Gerkowicz

Prost

1985

Graefe's Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

The objective of these studies was to find out whether iron administered extrabulbarly can penetrate inside the eyeball and whether this process can be checked by transconjunctival injections of desferrioxamine. Histological examination revealed that 12 months after the placing of iron in the orbit, an accumulation of the metal can be observed in the sclera, choroid, and retina of untreated animals. In the group of animals treated with desferrioxamine, iron did not penetrate into the eyeball, and only in some animals could its presence be found in superficial layers of the sclera. The possibility is discussed of using the drug for the treatment of conditions resulting from the presence of foreign bodies in the orbit.

show abstract

A micromethod for the determination of iron and total iron-binding capacity in intraocular fluids and plasma using electrothermal atomic absorption spectroscopy

McGahan

Fleisher

1986

Analytical Biochemistry

View full text Add to dashboard Cite

Experimental Investigations on the Penetration into the Eyeball of Iron Administered Intraorbitally

Cited by 5 publications

References 4 publications

Ocular siderosis: a misdiagnosed cause of visual loss due to ferrous intraocular foreign bodies—epidemiology, pathogenesis, clinical signs, imaging and available treatment options

Ocular siderosis: a misdiagnosed cause of visual loss due to ferrous intraocular foreign bodies—epidemiology, pathogenesis, clinical signs, imaging and available treatment options

Studies on the use of desferrioxamine in experimental ocular siderosis produced by extrabulbar administration of iron

A micromethod for the determination of iron and total iron-binding capacity in intraocular fluids and plasma using electrothermal atomic absorption spectroscopy

Contact Info

Product

Resources

About