Experimental isovalthinuria — Induction by hormones

Horiuchi, K.

doi:10.1016/0009-8981(65)90053-7

Cited by 2 publications

(9 citation statements)

References 12 publications

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“…The most commonly used method was that of Ubuka (1962) who described a method involving high‐voltage electrophoresis combined with paper chromatography for the identification of isovalthine and its related compounds. Later, ion exchange amino acid analysis was used allowing quantification of urinary isovalthine concentrations following induction (Ubuka, 1963; Horiuchi, 1965; Shimomura, 1965). It was reported however that paper electrophoresis was at least 10 times more sensitive than amino acid analysis (Fujii, 1969).…”

Section: Discovery Characterization Synthesis and Analysismentioning

confidence: 99%

“…However, during their studies to determine the predominant enantiomer present in urine, Ohmori and colleagues (1963) also noted that it was difficult to isolate urinary isovalthine as a single enantiomer without changing its configuration. Horiuchi (1965) reported that urinary isovalthine is sometimes present in two adjacent peaks on the amino acid analyser. Studies in our laboratory have shown that following acid hydrolysis of l‐isovalthine, two equal‐sized peaks eluting very close together are seen.…”

Section: Discovery Characterization Synthesis and Analysismentioning

confidence: 99%

“…It is possible that the increase in isovalthine excretion following l‐leucine administration in the experiment by Fukutome (1961) was either because of the animals being fed a leucine deficient diet to start with, or perhaps as a result of stress from the stomach tubing that was carried out in order to administer the l‐leucine. Interestingly, the stress hormones adrenaline and deoxycorticosterone have been shown to be inducers of isovalthine excretion in guinea‐pigs (Horiuchi, 1965).…”

Section: Isovalthine In Cat Urinementioning

confidence: 99%

“… The data are from * Fukutome (1961), † Fukutome (1962a), ‡ Ubuka (1963), § Horiuchi (1965), ¶ Shimomura (1965), ** Fukutome (1962b), †† Haruna (1961). …”

Section: Experimental Isovalthinuriamentioning

confidence: 99%

“…However excretion of isovalthine reoccurred following administration of methionine, presumably because methionine is able to replenish the glutathione pool. Isovalthinuria can also be induced in guinea‐pigs by the administration of prednisolone, dexamethasone, ACTH, deoxycorticosterone and adrenaline, but not by testosterone, oestradiol, progesterone, insulin or choline (Horiuchi, 1965). Shimomura (1965) reported that certain precursors of cholesterol synthesis such as isovaleric, β ‐methylcrotonic and β ‐methylglutaconic acids are strong inducers of isovalthinuria but other compounds such as acetic acid, acetoacetic acid, β ‐hydroxy‐ β ‐methylglutaric acid, squalene, α ‐ketoisocaproic acid and leucine were not.…”

Section: Isovalthine Induction and Biosynthesismentioning

confidence: 99%

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Mammalian isovalthine metabolism

Rutherfurd-Markwick

Rogers

Hendriks

2005

Animal Physiology Nutrition

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Summary Isovalthine is a branched‐chain sulphur amino acid, which has been found in the urine of normal cats. The concentrations of isovalthine in the urine of healthy adult cats are approximately 24–66 μmol/l and are not affected by the gender of the cat. Isovalthinuria can be induced in other species (rats, rabbits, guinea‐pigs, humans, dogs) following the administration of certain inducing agents such as some hypocholesterolaemic agents, bile acids, hormones or cholesterol precursors. The method of induction of isovalthinuria was studied extensively during the 1960s, and efforts were made to understand its biosynthesis. However, although the origin of the sulphur atom in isovalthine was shown to be from cysteine or methionine, the origin of the carbon skeleton remains unknown. Interest in isovalthine metabolism was generated in part because it was reportedly found in the urine of patients with hypercholesterolaemia. The validity of this finding however, was brought into question following reports that administration of the drug Bromural (α‐bromoisovalerylurea), to humans results in the generation of compounds which break down to yield isovalthine following acid hydrolysis. This article presents a review and discussion of the experimental data on isovalthine metabolism.

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Section: Discovery Characterization Synthesis and Analysismentioning

confidence: 99%

Section: Discovery Characterization Synthesis and Analysismentioning

confidence: 99%

Section: Isovalthine In Cat Urinementioning

confidence: 99%

“… The data are from * Fukutome (1961), † Fukutome (1962a), ‡ Ubuka (1963), § Horiuchi (1965), ¶ Shimomura (1965), ** Fukutome (1962b), †† Haruna (1961). …”

Section: Experimental Isovalthinuriamentioning

confidence: 99%

Section: Isovalthine Induction and Biosynthesismentioning

confidence: 99%

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