Experimental Keratitis Due to
            <i>Pseudomonas aeruginosa:</i>
            Model for Evaluation of Antimicrobial Drugs

Davis, Starkey D.; Chandler, John W.

doi:10.1128/aac.8.3.350

Cited by 32 publications

(6 citation statements)

References 8 publications

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“…In 1975, Davis and Chandler reported an improved method of examining and quantitating Pseudomonas keratitis using the guinea pig as a model [ 156 ]. One of the foci of this report was the use of intracorneal injection of bacteria so that the inoculum would be as precise as possible.…”

Section: Other Animalsmentioning

confidence: 99%

Animal Models of Bacterial Keratitis

Marquart

2011

BioMed Research International

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Bacterial keratitis is a disease of the cornea characterized by pain, redness, inflammation, and opacity. Common causes of this disease are Pseudomonas aeruginosa and Staphylococcus aureus. Animal models of keratitis have been used to elucidate both the bacterial factors and the host inflammatory response involved in the disease. Reviewed herein are animal models of bacterial keratitis and some of the key findings in the last several decades.

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Section: Other Animalsmentioning

confidence: 99%

Animal Models of Bacterial Keratitis

Marquart

2011

BioMed Research International

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“…The comparative in vivo studies that have been done indicate that there is no notable difference between tobramycin and gentamicin against Enterobacteriaceae [11,15,16], and that tobramycin is somewhat more effective than gentamicin in treating infections caused by Pseudomonas [1,5,6,13,14], If this is confirmed by further in vivo studies, it will indicate that the PDM medium is not suitable for sensitivity testing of Enterobacteriaceae and Pseudomonas spp. against the two most commonly used aminoglycosides.…”

Section: Discussionmentioning

confidence: 96%

Comparative <i>in vitro </i>Activity of Tobramycin and Gentamicin on Three Different Media

Sandven¹,

Lassen²,

Solberg³

et al. 1980

Chemotherapy

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The minimal inhibitory concentration for tobramycin and gentamicin against 488 clinical isolates of Enterobacteriaceae, Staphylococcus aureus and Pseudomonas spp. were obtained on three different solid media. The results obtained on Antibiotic Sensitivity Medium AB Biodisk (PDM) were markedly different from the results obtained on Mueller-Hinton (MH) and Diagnostic Sensitivity Test Agar Oxoid (DST). It was shown that tobramycin was significantly disfavored relative to gentamicin by PDM agar compared to MH and DST agar.

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“…The severity was graded using the system of Davis and Chandler (6). The severity was graded using the system of Davis and Chandler (6).…”

Section: Experimental Studymentioning

confidence: 99%

Pseudomonas aeruginosa: isolation from ocular tissues

et al. 1982

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Fifty strains of Pseudomonas aeruginosa isolated from human eyes were aeruginocin typed by the method of Shriniwas (1974) using ten indicator strains. These belonged to types A1 (3), B (2), F1 (1) and 14 (1). Fifteen (30%) were nontypable and 28 (56.0%) were unclassifiable presenting twenty inhibition patterns. The strains showed a wide range of antibiotic sensitivities. The highest number of insensitive strains were those obtained from corneal ulcers. Experimental keratitis produced by strains of pseudomonas was either mild, moderate or severe and was unrelated to their source. Mild keratitis was produced by types UC 7-, UC 79- and 14 isolated from pre-operative, corneal ulcer and post-operative patients. Lesions of moderate severity were produced by types 189+ & A1 whereas the severest pathology was produced by UC 23478-, B and UC 810- types. The fact that strain 23478- always produced severest pathology irrespective of whether originated from group I, II, or IV strongly suggests relationship of pathogenicity with aeruginocin type.

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Experimental Keratitis Due to Pseudomonas aeruginosa: Model for Evaluation of Antimicrobial Drugs

Cited by 32 publications

References 8 publications

Animal Models of Bacterial Keratitis

Animal Models of Bacterial Keratitis

Comparative <i>in vitro </i>Activity of Tobramycin and Gentamicin on Three Different Media

Pseudomonas aeruginosa: isolation from ocular tissues

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