Experimental knee pain impairs joint torque and rate of force development in isometric and isokinetic muscle activation

Rice, David A.; Mannion, Jamie; Lewis, Gwyn N.; McNair, Peter; Fort, Lana

doi:10.1007/s00421-019-04195-6

Cited by 22 publications

(19 citation statements)

References 57 publications

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“…There was a reduction in EMG amplitude at minute 1 and minute 2 in HYP compared to CTRL for both vasti muscles. This is in agreement with previous experimentally induced pain research (Graven-Nielsen et al 1997b ; Rice et al 2019 ). A reduction in EMG amplitude may reflect a reduction in maximal central motor output to the quadriceps, that is likely centrally mediated.…”

Section: Discussionsupporting

confidence: 93%

The effect of elevated muscle pain on neuromuscular fatigue during exercise

et al. 2021

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Purpose Muscle pain can impair exercise performance but the mechanisms for this are unknown. This study examined the effects of muscle pain on neuromuscular fatigue during an endurance task. Methods On separate visits, twelve participants completed an isometric time-to-task failure (TTF) exercise of the right knee extensors at ~ 20% of maximum force following an intramuscular injection of isotonic saline (CTRL) or hypertonic saline (HYP) into the vastus lateralis. Measures of neuromuscular fatigue were taken before, during and after the TTF using transcranial magnetic stimulation (TMS) and peripheral nerve stimulation. Results The mean pain intensity was 57 ± 10 in HYP compared to 38 ± 18 in CTRL (P < 0.001). TTF was reduced in HYP (4.36 ± 0.88 min) compared to CTRL (5.20 ± 0.39 min) (P = 0.003). Maximum voluntary force was 12% lower at minute 1 (P = 0.003) and 11% lower at minute 2 in HYP (P = 0.013) compared to CTRL. Voluntary activation was 4% lower at minute 1 in HYP compared to CTRL (P = 0.006) but not at any other time point (all P > 0.05). The TMS silent period was 9% longer at 100 s during the TTF in HYP compared to CTRL (P = 0.026). Conclusion Muscle pain reduces exercise performance through the excacerbation of neuromuscular fatigue that is central in origin. This appears to be from inhibitory feedback from group III/IV nociceptors which acts to reduce central motor output.

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Section: Discussionsupporting

confidence: 93%

The effect of elevated muscle pain on neuromuscular fatigue during exercise

et al. 2021

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“…Indeed, it has been proposed that motor command as measured as EMG in painful muscles (Taylor et al., 2016) is reduced due to pain‐related signaling to pain processing cerebral regions (Graven‐Nielsen, 2006). In the present study, we found that a higher pain sensation in hypertonic condition paralleled a reduced activation of the VL and BF during exercise, corroborating results obtained in different exercise modes after an induced muscle or joint pain (Ervilha et al., 2005; Falla et al., 2007; Farina et al., 2005; Rice et al., 2019). The finding that pain reduced the VL and BF EMG although the power‐matched constant cycling is not necessarily a contradiction, as the experimentally induced muscle pain may have increased the recruitment of other agonist or synergist muscles (not measured in the present study) not affected by the hypertonic injection in order to maintain the target power output.…”

Section: Discussionsupporting

confidence: 89%

Effects of experimentally induced muscle pain on endurance performance: A proof‐of‐concept study assessing neurophysiological and perceptual responses

et al. 2021

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Pain arising from exercise potentiates fatigue and impairs the performance of endurance exercise. We assessed neurophysiological and perceptual responses to endurance exercise performed under experimentally induced muscle pain by a model that separates muscle pain from muscle fatigue. After a series of pilot studies investigating different hypertonic saline volumes, 17 healthy males performed a preliminary VO 2PEAK test before performing a familiarization of the cycling time-to-exhaustion exercise (80% of the peak power output in the VO 2PEAK test). Participants, performed a baseline exercise session before the sessions with hypertonic and isotonic saline injections in the vastus lateralis of both legs, in a crossover and counterbalanced design. Neurophysiological and perceptual responses such as electroencephalography (EEG) in frontal, prefrontal, parietal, and motor cortex, electromyography (EMG) of the vastus lateralis and biceps femoris muscles, ratings of perceived exertion (RPE), pain sensation, and affective valence were measured at rest and during exercise. The hypertonic injection reduced the resting EEG alpha-beta ratio in the frontal and prefrontal cortex. When compared to exercise performed after the isotonic injection (430.5 ± 152.6 s), hypertonic injection shortened the time-to-exhaustion (357.5 ± 173.0 s), reduced the EMG of the assessed muscles, and increased the muscle co-contraction during exercise. The hypertonic injection also reduced the EEG alpha-beta ratio in the prefrontal and parietal cortex, increased RPE and pain sensation, and reduced affective valence during exercise. This proof-of-concept study showed that hypertonic injection-induced muscle pain reduced endurance performance, promoting centrally mediated alterations in motor command and cortical activation, as well as an interplay of perceptual responses.

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“…The rate of force development (RFD)-which is basically obtained from the ascending part of the force-time curve of an explosive contraction either as a mean time-locked value or a maximal force per time ratio-has received increasing interest in the last few years for the evaluation of explosive strength in multiple situations (Maffiuletti et al, 2016;Rodriguez-Rosell et al, 2017). As such, RFD has been shown to be more sensitive than MVF to detect chronic changes induced for example by aging (Thompson et al, 2014), immobilization/disuse (de Boer et al, 2007), strength training (Andersen et al, 2010) and rehabilitation (Angelozzi et al, 2012), but also acute adjustments associated to exercise (Buckthorpe et al, 2014), muscle damage (Peñailillo et al, 2015), and pain (Rice et al, 2019). Despite being more functionally relevant than pure maximal strength (Tillin et al, 2010;McLellan et al, 2011), RFD-particularly the one derived from the earlier phase of the contraction (≤100 ms; early RFD)-has been suggested to be largely influenced by neural mechanisms, mainly in relation with motor unit behavior (Del Vecchio et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Rate of Force Development as an Indicator of Neuromuscular Fatigue: A Scoping Review

D’Emanuele

Maffiuletti

Tarperi

et al. 2021

Front. Hum. Neurosci.

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Because rate of force development (RFD) is an emerging outcome measure for the assessment of neuromuscular function in unfatigued conditions, and it represents a valid alternative/complement to the classical evaluation of pure maximal strength, this scoping review aimed to map the available evidence regarding RFD as an indicator of neuromuscular fatigue. Thus, following a general overview of the main studies published on this topic, we arbitrarily compared the amount of neuromuscular fatigue between the “gold standard” measure (maximal voluntary force, MVF) and peak, early (≤100 ms) and late (>100 ms) RFD. Seventy full-text articles were included in the review. The most-common fatiguing exercises were resistance exercises (37% of the studies), endurance exercises/locomotor activities (23%), isokinetic contractions (17%), and simulated/real sport situations (13%). The most widely tested tasks were knee extension (60%) and plantar flexion (10%). The reason (i.e., rationale) for evaluating RFD was lacking in 36% of the studies. On average, the amount of fatigue for MVF (−19%) was comparable to late RFD (−19%) but lower compared to both peak RFD (−25%) and early RFD (−23%). Even if the rationale for evaluating RFD in the fatigued state was often lacking and the specificity between test task and fatiguing exercise characteristics was not always respected in the included studies, RFD seems to be a valid indicator of neuromuscular fatigue. Based on our arbitrary analyses, peak RFD and early phase RFD appear even to be more sensitive to quantify neuromuscular fatigue than MVF and late phase RFD.

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Experimental knee pain impairs joint torque and rate of force development in isometric and isokinetic muscle activation

Cited by 22 publications

References 57 publications

The effect of elevated muscle pain on neuromuscular fatigue during exercise

The effect of elevated muscle pain on neuromuscular fatigue during exercise

Effects of experimentally induced muscle pain on endurance performance: A proof‐of‐concept study assessing neurophysiological and perceptual responses

Rate of Force Development as an Indicator of Neuromuscular Fatigue: A Scoping Review

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