Experimental Labyrinthine Lesions through Stylomastoid Foramen

Kumagami, Hidehaku; Nishida, Hiroaki; Dohi, Katsunori

doi:10.1159/000275293

Cited by 32 publications

(3 citation statements)

References 4 publications

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“…In the experimental studies, various vi ruses and chemical solutions, such as Indian ink injected into the facial nerve through the stylomastoid foramen, reached the vestibulofacial anastomosis and then the statoacoustic nerve, in the internal auditory canal [10,11]. This route may be one of the passages of tumor extension in the present case.…”

Section: Discussionmentioning

confidence: 59%

Poorly Differentiated Fibrosarcoma (Spindle Cell Sarcoma) Involving the Temporal Bone

Yoshihara¹,

Igarashi²

1986

ORL

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A case of metastatic fibrosarcoma of the temporal bone was studied histopathologically. The primary site of this tumor was the posterior neck region. The initial major symptom of the patient was a left facial nerve paralysis. Although the patient underwent a suboccipital posterior craniectomy, radio-, and chemotherapy, she eventually died from multiple metastases. Histological examination of the temporal bones showed an extensive tumor invasion in the external auditory canal, middle ear cavity, middle ear muscle, tympanic membrane, mastoid cavity, petrous apex, facial nerve, and superior division (distal segment) of the vestibular nerve (left ear). The route from the stylomastoid foramen to the superior division of the vestibular nerve via the facial nerve canal could be one of the possible passages of tumor invasion.

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Section: Discussionmentioning

confidence: 59%

Poorly Differentiated Fibrosarcoma (Spindle Cell Sarcoma) Involving the Temporal Bone

Yoshihara¹,

Igarashi²

1986

ORL

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“…Ten days after the last booster injection, the inner car was chal lenged with antigen as described previously [9,15]. Briefly, the right side of the stylomastoid foramen o f actively sensitized guinea pigs was exposed by postauricular incision under general anesthesia with sodi um pentobarbital (15 mg/kg body mass, i.p.)…”

Section: Antigen Challenge To the Inner Earmentioning

confidence: 99%

Recurrent Hearing Impairment and Nystagmus Induced by Repeated Antigen Exposure in Actively Sensitized Guinea Pigs

Minoda

Masuyama²,

Toriya³

et al. 1996

Int Arch Allergy Immunol

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Although many studies have suggested a relation between allergy and Ménière’s disease, the pathophysiology of this condition remains controversial. The aim of this study was to clarify whether an anaphylactic reaction in the inner ear can disturb hearing and equilibrium, and whether such disturbances recur in response to repeated anaphylactic reactions. Increases in audiological threshold, nystagmus, and endolymphatic hydrops were observed in response to a single exposure to antigen administered to actively sensitized guinea pigs. The increase in audiological threshold was maximal 10 h after antigen challenge (p < 0.005) and returned to the baseline level after 7 days. Nystagmus and the increase in audiological threshold induced by antigen exposure were inhibited by prior administration of pemirolast potassium (p < 0.05), an inhibitor of chemical mediator release from mast cells. A second challenge with antigen 7 days after the first also induced an increase in audiological threshold (p < 0.05) and nystagmus. These results suggest that studies of repeated antigen challenge in actively sensitized animal models may increase our understanding of the pathophysiology of Ménière’s disease.

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“…Most of the occurrences were spontaneous and reflected the inflammatory reaction of the epithelial lining of the endolymphatic space (2,3). Various methods have been used to induce endolymphatic hydrops in animals, including intravenous injection of horse serum (4), tubercle bacilli (4), egg albumin (5), or horseradish peroxidase (6); injection of human serum through the stylomastoid foramen has also been used (7). Other methods include surgical obstruction of endolymphatic duct (8,9), injection of ethacrynic acid (10), and infrasound acoustic trauma (11).…”

mentioning

confidence: 99%

Type II Collagen-Induced Autoimmune Endolymphatic Hydrops in Guinea Pig

Yoo

Yazawa

Tomoda

et al. 1983

Science

120

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Endolymphatic hydrops was induced in guinea pigs by immunizing them with native bovine type II collagen. Histopathologic changes consisted of moderate extension of the Reissner's membrane, spiral ganglion degeneration, atrophied organ of Corti, and mild atrophy of the surface epithelium in the endolymphatic duct. These findings suggest that an immune response directed against type II collagen--a type of collagen found in the membranous labyrinth, subepithelial layer of the endolymphatic duct, spiral ligament, and enchondral layer of the otic capsule--may induce endolymphatic hydrops.

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Experimental Labyrinthine Lesions through Stylomastoid Foramen

Cited by 32 publications

References 4 publications

Poorly Differentiated Fibrosarcoma (Spindle Cell Sarcoma) Involving the Temporal Bone

Poorly Differentiated Fibrosarcoma (Spindle Cell Sarcoma) Involving the Temporal Bone

Recurrent Hearing Impairment and Nystagmus Induced by Repeated Antigen Exposure in Actively Sensitized Guinea Pigs

Type II Collagen-Induced Autoimmune Endolymphatic Hydrops in Guinea Pig

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