Experimental Leukemias in the Rat

Shay, Harry; Gruenstein, Margot; Harris, Charles

doi:10.1159/000205008

Cited by 25 publications

(8 citation statements)

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“…Trhe discovery of numerous papillary and non-papillary duct or ductule earcinomas in the rat agrees with the findings of Geschickter (1943), andNelson (1944), who used oestrogens, and Cantarow, Stasney and Paschkis (1948), Shay, Harris and Gruenstein (1952), Ross et al (1953), Howell (1959 and Huggins, Briziarelli and Sutton (1959) Scarf, Ross and Skoryna (1952) found that nipple ligation did not change the final tumour incidence. In the small experiment described here in which unilateral nipplectomies were performed, llO significant differences in either tumour incidence or time of tumour appearance were apparent.…”

Section: Discussionsupporting

confidence: 79%

The histogenesis of mammary tumours induced in the rat by chemical carcinogens

Pj¹

1965

Br J Cancer

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WHEREAS many studies deal with the histogenesis of mammary tumours in mice and in man (Bonser, Dossett and Jull, 1961), the literature contains relatively little information on the development of breast tumours in the rat (Noble and Cutts, 1959). Geschickter (1943) described the early neoplastic lesions induced by chronic oestrogenic stimulation but later studies employing chemical carcinogens for the induction of breast tumours were primarily concerned with the histology of advanced neoplasms (Ross, Scarf and Skoryna, 1953;Young et al.. 1963). It was the purpose of the experiments presented in this paper to fill the gap.The biological behaviour and endocrine response of rat mammary cancers indicate a greater similarity to human disease than those of the mouse (Huggins, 1960). In the human, mammary carcinoma arises most frequently in the ducts and ductules (Cheatle and Cutler, 1931; Muir, 1941), whereas in the mouse most carcinomas are of acinar origin (Bonser, 1945(Bonser, , 1954. The question therefore arose whether or not some interconnection existed between site of origin and biological behaviour-i.e. did mammary carcinoma in the rat arise preferentially in ductal structures?For the induction of breast tumours the three compounds, 2-acetylaminofluorene (2-AAF), 20-methyl-cholanthrene (MC) and 7,12-dimethylbenz(a)anthracene (DMBA) were chosen. The three locally available strains of rats were tested for their response to these carcinogens in preliminary trials. Wistar rats were the most susceptible and were subsequently used in the majority of experiments. MATERIALS AND METHODSOne hundred and twenty-six female rats were used in this study. The aniimals were divided into 5 experimental groups and treated as follows:Group A.-56 Wistar rats received 2-AAF in a wet diet for 13 weeks (4 mg. 2-AAF per rat per day for 9 weeks then 2 mg. per day per rat for 4 weeks). Seven of these animals were subjected to left-sided nipplectomies (6 nipples) under ether anaesthesia with prior removal of the hair from the pelt by the application of barium sulphide paste.Group B.-16 Wistars, 8 piebalds and 8 black rats were each given a single gastric instillation of DMBA (Huggins, Grand and Brillantes, 1961) by means of a 17-gauge needle tipped by a smooth soft metal perforated bulb and connected to a syringe. Each rat received 1 mg. of DMBA per 7 g. of body weight. The DMBA dose of 15-17 mg. was dissolved in 1 ml. of warm almond oil.

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Section: Discussionsupporting

confidence: 79%

The histogenesis of mammary tumours induced in the rat by chemical carcinogens

Pj¹

1965

Br J Cancer

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“…in the rat (Fig. 2, Group II), and confirms similar findings by Shay, Harris and Gruenstein (1960). This characteristic is also shared by human breast cancer, the incidence of which is significantly reduced by oophorectomy before the age of 40 (Feinlieb and Garrison, 1969).…”

Section: Disgussionsupporting

confidence: 85%

The Influence of Immunosuppression and Sex Hormone Manipulation on Mammary Tumounrogensis in Rat

Hunt

1973

Aust J Exp Biol Med

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Summary The 7.12 dimethyl benznthracene induced rat mammary tumour model was chosen as system for the investigation of the effect of sex hormone and immunosuppression on later incidence of tumours. Prior oophorectomy significantly reduced tumour incidence. No increase in tumour incidence after immunosuppression with antithymocyte globulin was shown unless the rats were previously oophorectomised. Subsequent treatment with oestradiol restored the carcinogenic action of 7‐12 dimethyl benzanthracene in oophorctomised animals and testosterone inhibited tumour development in oophorectomised, immunosuppressed rats.

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“…Y .1)evelopment of mammary adenocarcinoma in rats following oral administration of 3methylcholanthrene has been reported( 1,2 ) .These observations also indicated that induced mammary cancers were hormone-dependent. Imnzunol., 1959, v8.3 2.…”

mentioning

confidence: 83%