Experimental Lung Xenografting

PiersonIII, R. N.; Pino-Chavez, Gilda

doi:10.1007/978-3-642-60572-7_35

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Taking Practical Steps Forward On Xenotransplantation1

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2018

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Cited by 2 publications

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“…As of today we do know that we can reproducibly make pigs with at least 8 well‐chosen and well‐placed gene edits from the standpoint of organ tolerability in a baboon. The result of this has been a 100‐fold increase in Xenolung survival time compared to that achievable with alpha‐gal knockout alone, the sole gene edit from which our effort began …”

Section: Taking Practical Steps Forward On Xenotransplantationmentioning

confidence: 99%

A personal perspective on the science, ethics, and commercialization of xenotransplantation

Rothblatt

2018

Xenotransplantation

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A parent of a child with a fatal lung disease decides to try to save her first with improved pharmaceuticals to hold the disease at bay, and then with an unlimited supply of transplantable lungs to cure the disease and manage the consequences of eventual organ rejection. The parent needs to surmount science, ethics, and commercialization issues for organ transplantation to be a practical cure, and several of those issues are particularly difficult for xenotransplanation. After half-a-decade of effort, the parent's personal journey has resulted in a 100-fold increase in the number of hours that pulmonary xenografts are viable, but still remains significantly shy of commercial viability and still leaves some ethical issues open.

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Section: Taking Practical Steps Forward On Xenotransplantationmentioning

confidence: 99%