Experimental Lymphedema of the Intestinal Tract and Its Relation to Regional Cicatrizing Enteritis*

Reichert, Frederick Leet; Mathes, Mary E.

doi:10.1097/00000658-193610440-00013

Cited by 101 publications

(26 citation statements)

References 1 publication

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“…As early as 1936, an experimental study on mesenteric lymphatic blocking revealed histological alterations similar to Crohn's disease [8]. Dilated lacteals are a common histological finding in Crohn's disease [9], The main disease process in regional enteritis has been described as a progressive granulo matous lymphangitis [10].…”

Section: Discussionmentioning

confidence: 99%

Reduced Intestinal Protein Loss in Crohn’s Disease after Lymphovenous Anastomosis

Wellmann¹,

Luska²,

Slender³

et al. 1985

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In a 27-year-old patient suffering from Crohn’s disease covering nearly the entire small intestine, the major problem was a marked protein-losing enteropathy which required long-term intravenous replacement. Accidentally, we disclosed a dilated thoracic duct with incompetent valves and stenosis at the junction into the subclavian vein in this patient. To reduce the intestinal protein loss, an anastomosis was performed between the thoracic duct and the internal jugular vein. Subsequently the intestinal protein loss dropped from 40 to 26% and replacement of proteins could be reduced. The patient was observed for 4 years postoperatively and the therapeutic effect continued. Besides this therapeutic aspect, the present case gives cause to consider the possible role of the lymphatics in the pathogenesis of Crohn’s disease.

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Section: Discussionmentioning

confidence: 99%

Reduced Intestinal Protein Loss in Crohn’s Disease after Lymphovenous Anastomosis

Wellmann¹,

Luska²,

Slender³

et al. 1985

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“…Poppe (10) applying similar techniques to those o f Reichert and Mathes (12) in the dog colon, produced mucosal ulceration. Kalima Smith (13) The increasing incidence o f Crohn's disease calls for intensified effort to discover its patho genesis.…”

Section: Experimental Lymphatic Obstructionmentioning

confidence: 96%

Mesenteric Lymphatic Obstruction in Crohn’s Disease

Heatley¹,

Bolton²,

Hughes³

et al. 1980

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The lymphatic drainage of diseased and normal bowel was studied in 21 patients undergoing surgery for Crohn’s disease. Mesenteric lymphatic obstruction was a consistent feature, identified in areas of small bowel macroscopically affected by Crohn’s disease. This finding was also observed in some areas of apparently unaffected small bowel. Subsequent examination of these areas confirmed the presence of early Crohn’s disease. This method of study may prove to be of value for determining the extent of operative resection in patients with Crohn’s disease. Experimental lymphatic obstruction in animals failed to produce pathological changes of Crohn’s disease, suggesting that this feature is an epiphenomenon and is not of primary importance in the pathogenesis of regional enteritis.

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“…Eine Reihe von Autoren nim m t dies an, da es tierexperim entell gelungen ist, durch Injektionen von sklerosierenden Lösungen in Mesenterialdrüsen und Lymphgefäße der Darmwand eine entzündli che Schwellung der Darm wand und bei gleichzeitiger i. v. Injektion einer Coli-Aufschwemmung auch Ulzerationen zu erzeugen, Prozesse also, die gewisse Ähnlichkeit mit der Crohn'schen Enteritis haben [15] [8,14].…”

Section: Editorialunclassified

Gedanken zur Aetiologie der Enteritis regionalis Crohn

Hafter¹

1960

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Experimental Lymphedema of the Intestinal Tract and Its Relation to Regional Cicatrizing Enteritis*

Cited by 101 publications

References 1 publication

Reduced Intestinal Protein Loss in Crohn’s Disease after Lymphovenous Anastomosis

Reduced Intestinal Protein Loss in Crohn’s Disease after Lymphovenous Anastomosis

Mesenteric Lymphatic Obstruction in Crohn’s Disease

Gedanken zur Aetiologie der Enteritis regionalis Crohn

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