Experimental measurement – correlation of solubility and dissolution thermodynamics study of itraconazole in pure monosolvents at various temperatures

Jagdale, Sachin; Nawale, Rajesh B.

doi:10.1080/03639045.2021.1879841

Cited by 5 publications

(4 citation statements)

References 80 publications

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“…In terms of thermodyanmics models, the solid–liquid equilibrium has been studied using thermodynamics equations in order to obtain a predictive model for the solubility of different materials. ,− …”

Section: Resultsmentioning

confidence: 99%

“…Subsequently, the obtained samples were characterized by both gravimetry and chromatography. Additionally, in order to propose a predictive solubility model, the solid–liquid equilibrium was studied using three different activity coefficient models, namely the nonrandom two-liquid (NRTL) model, the UNIQUAC model, and the Wilson equation, whose binary interaction parameters were fitted following a procedure similar to that proposed in previous solubility studies. ,− Such models require knowing the melting point and the enthalpy of vaporization of CBD, which were obtained using differential scanning calorimetry (DSC). − …”

Section: Introductionmentioning

confidence: 99%

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Experimental Solubility of Cannabidiol (CBD) in Different Organic Solvents

Pulido Bonilla,

Orozco,

Gil Chaves

et al. 2023

Ind. Eng. Chem. Res.

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In the present work, the solubility of cannabidiol (CBD) is reported as a function of temperature (253.1−310.1 K) in four pure solvents: n-pentane, n-hexane, n-heptane, and isooctane. Experimental data were obtained under a local pressure of 74 kPa by an isothermal method using an in situ filter to sample only the homogeneous liquid phase. The samples were analyzed by gravimetry and gas chromatography coupled with a flame ionization detector (GC-FID). A thermal analysis of the CBD by way of differential scanning calorimetry (DSC) was also carried out in order to determine its melting point and enthalpy of fusion. The solid−liquid equilibrium was theoretically studied using the Wilson equation, the nonrandom two-liquid (NRTL), and the UNIQUAC activity coefficient models in order to obtain a predictive model for CBD solubility. It was found that the melting point and the enthalpy of fusion for CBD were 341.4 ± 0.4 K and 21 ± 3 kJ mol −1 , respectively. The mole fraction solubility of CBD was 2.44 × 10

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Experimental Solubility of Cannabidiol (CBD) in Different Organic Solvents

Pulido Bonilla,

Orozco,

Gil Chaves

et al. 2023

Ind. Eng. Chem. Res.

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“…Thus, the solubility data of solid solutes in monosolvents could be useful in purification, crystallization, drug development processes, and formulation development. 19,20 Temperaturedependent solubility data of poorly water-soluble drugs in mono or mixed solvents are extremely useful in various research areas in pharmaceutical industries. 21−24 formamide (DMF), N,N-dimethyl acetamide (DMA), dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP), ethylene glycol (EG), propylene glycol (PG), 1,4-butanediol (BDOH), glycerin, polyethylene glycol-200 (PEG-200), PEG-400, PEG-600, and water have not been reported in the literature.…”

Section: ■ Introductionmentioning

confidence: 99%

“…A perusal of the structure of SAT indicates that the molecule is highly aromatic and the functional groups may not contribute much to the aqueous solubility. − Moreover, unfortunately the information about its physicochemical properties such as solubility is not yet complete. Thus, the solubility data of solid solutes in monosolvents could be useful in purification, crystallization, drug development processes, and formulation development. , Temperature-dependent solubility data of poorly water-soluble drugs in mono or mixed solvents are extremely useful in various research areas in pharmaceutical industries. − Temperature-dependent solubility data of SAT in monosolvents such as methanol (MeOH), ethanol (EtOH), 1-propanol (1-PrOH), 2-propanol (2-PrOH), formamide, 1,4-dioxane, N,N -dimethyl formamide (DMF), N,N -dimethyl acetamide (DMA), dimethyl sulfoxide (DMSO), N -methyl-2-pyrrolidone (NMP), ethylene glycol (EG), propylene glycol (PG), 1,4-butanediol (BDOH), glycerin, polyethylene glycol-200 (PEG-200), PEG-400, PEG-600, and water have not been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Modeling and Solubility Study of Satranidazole in Different Monosolvents at Different Temperatures

Rathi¹,

Kale

Jouyban

2021

J. Chem. Eng. Data

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The solubility study of drugs in aqueous and organic solvents has practical importance in pharmaceutical industries. In this research work, the solubilities of satranidazole (SAT) were determined in 18 monosolvents, namely, methanol (MeOH), ethanol (EtOH), 1-propanol (1-PrOH), 2-propanol (2-PrOH), formamide, 1,4-dioxane, N,N-dimethyl formamide (DMF), N,N-dimethyl acetamide (DMA), dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP), ethylene glycol (EG), propylene glycol (PG), 1,4-butanediol (BDOH), glycerin, polyethylene glycol-200 (PEG-200), PEG-400, PEG-600, and water, at five different temperatures (T = 293.2–313.2 K) and atmospheric pressure (p = 0.1 MPa). Experimental solubilities expressed in the molar fraction of SAT were correlated well with thermodynamic models including van’t Hoff model, Apelblat model, Buchowski–Ksiazczak model, and polynomial empirical model. The molar fraction solubility of SAT was recorded highest in NMP (7.963 × 10–2 at T = 293.2 K) followed by DMSO, formamide, DMF, DMA, PEG-600, PEG-400, PEG-200, 1,4-dioxane, PG, EG, BDOH, glycerin, MeOH, EtOH, 1-PrOH, 2-PrOH, and water as expected over the entire temperature range investigated.

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