Experimental Measurements of Energy Augmentation for Mechanical Circulatory Assistance in a Patient-Specific Fontan Model

Chopski, Steven G.; Rangus, Owen M.; Moskowitz, William B.; Throckmorton, Amy L.

doi:10.1111/aor.12255

Cited by 8 publications

(9 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No retrograde velocities in the SVC were observed in this study, even at the highest rotational speed. This finding correlates previous results with regard to hydraulic testing of the same TCPC vessel configuration . Increasing the mixing that naturally occurs in the TCPC junction while removing the venous congestion, not activating or causing blood trauma, and not overloading a failing single ventricle are important steps toward restoring hemodynamic stability in these patients.…”

Section: Discussionsupporting

confidence: 88%

Three‐Dimensional Laser Flow Measurements of a Patient‐Specific Fontan Physiology With Mechanical Circulatory Assistance

et al. 2015

Self Cite

View full text Add to dashboard Cite

Mechanical assistance of the Fontan circulation is hypothesized to enhance ventricular preload and improve cardiac output; however, little is known about the fluid dynamics. This study is the first to investigate the three-dimensional flow conditions of a blood pump in an anatomic Fontan. Laser measurements were conducted having an axial flow impeller in the inferior vena cava. Experiments were performed for a physiologic cardiac output, pulmonary arterial flows, and pump speeds of 1000-4000 rpm. The impeller had a modest effect on the flow conditions entering the total cavopulmonary connection at low pump speeds, but a substantial impact on the velocity at higher speeds. The higher speeds of the pump disrupted the recirculation region in the center of the anastomosis, which could be advantageous for washout purposes. No retrograde velocities in the superior vena cava were measured. These findings indicate that mechanical assistance is a viable therapeutic option for patients having dysfunctional single ventricle physiology.

show abstract

Section: Discussionsupporting

confidence: 88%

Three‐Dimensional Laser Flow Measurements of a Patient‐Specific Fontan Physiology With Mechanical Circulatory Assistance

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Hydraulic testing of these configurations was accomplished in Chopski et al. and found that the addition of the stents significantly affected the pressure generation of the pump. The a gainst‐with stent demonstrated a higher pressure generation and increase in flow over the selected range of rotational speeds, than either the super‐diffuser stent or the impeller alone.…”

Section: Discussionmentioning

confidence: 99%

“…A hydraulic flow loop (Fig. ) was used to circulate the experimental fluid through the anatomic Fontan model at the predetermined cardiac output level . To match the refractive index of clear urethane resin, a mixture of diethyl phthalate and ethanol (Sigma‐Aldrich Co., LLC, St. Louis, MO, USA, CAS: 84‐66‐2 and CAS: 64‐17‐5) was determined to match the material refractive index of 1.49 of the TCPC model.…”

Section: Methodsmentioning

confidence: 99%

Stereo-Particle Image Velocimetry Measurements of a Patient-Specific Fontan Physiology Utilizing Novel Pressure Augmentation Stents

et al. 2015

Self Cite

View full text Add to dashboard Cite

Single ventricle anomalies are a challenging set of congenital heart defects that require lifelong clinical management due to progressive decline of cardiovascular function. Few therapeutic devices are available for these patients, and conventional blood pumps are not designed for the unique anatomy of the single ventricle physiology. To address this unmet need, we are developing an axial flow blood pump with a protective cage or stent for Fontan patients. This study investigates the 3-D particle image velocimetry measurements of two cage designs being deployed in a patient-specific Fontan anatomy. We considered a control case without a pump, impeller placed in the inferior vena cava, and two cases where the impeller has two protective stents with unique geometric characteristics. The experiments were evaluated at a cardiac output of 3 L/min, a fixed vena caval flow split of 40%/60%, a fixed pulmonary arterial flow split of 50%/50%, and for operating speeds of 1000-4000 rpm. The introduction of the cardiovascular stents had a substantial impact on the flow conditions leaving the pump and entering the cavopulmonary circulation. The findings indicated that rotational speeds above 4000 rpm for this pump could result in irregular flows in this specific circulatory condition. Although retrograde flow into the superior vena cava was not measured, the risk of this occurrence increases with higher pump speeds. The against-with stent geometry outperformed the other configurations by generating higher pressures and more energetic flows. These results provide further support for the viability of mechanical cavopulmonary assistance as a therapeutic treatment strategy for Fontan patients.

show abstract

“…The device is intended for short‐term MCS of up to 4 weeks with percutaneous pump replacement. The development of this device has been successful with computational analyses, PIV studies, and hemolysis testing leading to advanced designs .…”

Section: New Mcs Devices Under Developmentmentioning

confidence: 99%

Mechanical Circulatory Support Devices for Pediatric Patients With Congenital Heart Disease

et al. 2016

Self Cite

View full text Add to dashboard Cite

The use of mechanical circulatory support (MCS) devices is a viable therapeutic treatment option for patients with congestive heart failure. Ventricular assist devices, cavopulmonary assist devices, and total artificial heart pumps continue to gain acceptance as viable treatment strategies for both adults and pediatric patients as bridge-to-transplant, bridge-to-recovery, and longer-term circulatory support alternatives. We present a review of the current and future MCS devices for patients having congenital heart disease (CHD) with biventricular or univentricular circulations. Several devices that are specifically designed for patients with complex CHD are in the development pipeline undergoing rigorous animal testing as readiness experiments in preparation for future clinical trials. These advances in the development of new blood pumps for patients with CHD will address a significant unmet clinical need, as well as generally improve innovation of the current state of the art in MCS technology.

show abstract

Experimental Measurements of Energy Augmentation for Mechanical Circulatory Assistance in a Patient-Specific Fontan Model

Cited by 8 publications

References 26 publications

Three‐Dimensional Laser Flow Measurements of a Patient‐Specific Fontan Physiology With Mechanical Circulatory Assistance

Three‐Dimensional Laser Flow Measurements of a Patient‐Specific Fontan Physiology With Mechanical Circulatory Assistance

Stereo-Particle Image Velocimetry Measurements of a Patient-Specific Fontan Physiology Utilizing Novel Pressure Augmentation Stents

Mechanical Circulatory Support Devices for Pediatric Patients With Congenital Heart Disease

Contact Info

Product

Resources

About