Experimental methods of an anti-CyHV-3 directed campaign – Prospects, efficiency and safety

Acyclovir inhibits CyHV‐3 replication in a dose‐dependent manner. An in vitro study

“…The virus persists in a latent form in asymptomatic survivors and under some circumstances, can get reactivated and subsequently be transmitted to naïve fish, which facilitates its spread and duration in the environment (Eide et al, 2011). Numerous strategies are being explored to face CyHV‐3‐induced mortalities, and further research in this field is needed (Troszok et al, 2021). One of these strategies refers to the application of nucleoside analogues.…”

“…Numerous strategies are being explored to face CyHV-3-induced mortalities, and further research in this field is needed (Troszok et al, 2021). One of these strategies refers to the application of nucleoside analogues.…”

Thyme essential oil inhibits intracellular replication of CyHV‐3 and inactivates extracellular virus. An in vitro study

“…The vast majority of these studies were juxtaposed in recent reviews by Boutier et al (2019) and Troszok et al (2021). However, none of these methods has been sufficiently developed to become commercially available in the majority of the world (Boutier et al, 2015; Troszok et al, 2021). For that reason, a safe solution to the KHVD outbreak problem is needed.…”

“…Various experimental methods of prevention and treatment of KHVD were explored in numerous studies, including silencing with siRNA, the use of immunostimulants, vaccinations, selection of broodstock for increased resistance and the use of antiviral drugs. The vast majority of these studies were juxtaposed in recent reviews by Boutier et al (2019) and Troszok et al (2021).…”

“…However, none of these methods has been sufficiently developed to become commercially available in the majority of the world (Boutier et al, 2015;Troszok et al, 2021). For that reason, a safe solution to the KHVD outbreak problem is needed.…”