2019
DOI: 10.1016/j.repbio.2019.06.001
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Experimental mild increase in testicular temperature has drastic, but reversible, effect on sperm aneuploidy in men: A pilot study

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Cited by 16 publications
(3 citation statements)
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“…However, seasonal influence on outcome of IVF in human is still under discussion. The effect of seasonal change on natural conception mainly in two ways: weather condition and temperature affect male sperm quality 8 , sunshine exposure influence female’s ovulation. The optimal spermatogenesis in man requires 2–6°C lower testicular temperature than body and any rise above physiological temperature of the testes has adverse effect on spermatogenesis 9,10 .…”
Section: Discussionmentioning
confidence: 99%
“…However, seasonal influence on outcome of IVF in human is still under discussion. The effect of seasonal change on natural conception mainly in two ways: weather condition and temperature affect male sperm quality 8 , sunshine exposure influence female’s ovulation. The optimal spermatogenesis in man requires 2–6°C lower testicular temperature than body and any rise above physiological temperature of the testes has adverse effect on spermatogenesis 9,10 .…”
Section: Discussionmentioning
confidence: 99%
“…Negative effects are also observed in experiments in which the scrotum is insulated to increase temperature. For example, scrotal insulation studies in livestock and humans have found decreased sperm concentration, motility, and viability, as well as increased morphological abnormalities and DNA damage ( Vogler et al, 1993 ; Abdelhamid et al, 2019 ; Garcia-Oliveros et al, 2020 ; Shahat et al, 2020 ).…”
Section: How Temperature Affects Sperm Traitsmentioning
confidence: 99%
“…Elevated testicular temperature can result in a signifi-cant but reversible decrease in spermatogenesis and total sperm count, potentially leading to azoospermia. This is due to an increased loss of germ cells, reduced expression of proliferating cell nuclear antigen, and an imbalance between oxidative stress and antioxidant capacity [9][10][11]. Various treatments aimed at enhancing spermatogenesis have been investigated, including the use of vitamin C and/ or vitamin E along with other antioxidants.…”
Section: Introductionmentioning
confidence: 99%