Experimental model of autism spectrum disorder induced by prenatal administration of propionic acid to Wistar rats
V. S. Boyarkin,
I. G. Kapitsa,
T. A. Voronina
Abstract:Relevance. Autism spectrum disorder (ASD) is a developmental disorder of the brain with unclear etiology and pathophysiology, characterized by impaired social communication, stereotypic or repetitive behavior, and varying degrees of mental retardation. One of the environmental factors that have an adverse effect on pregnant women and embryo development is propionic acid (PPA), which is a secondary metabolite of the intestinal microbiota and is widely used as a food preservative. Under physiological conditions,… Show more
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