Experimental model of saccular abdominal aortic aneurysm in swines with pericardium sac

Abstract

Objective:To consider modifications in an experimental model of saccular aortic aneurysm, aiming at better reproducibility, to be used in the development of vascular prostheses.Methods:Experimental study in two phases, developed in the Center of Experimental Surgery and Bioterium (CCEB) of the University of Health Sciences of Alagoas (UNCISAL), with 11 hybrid swine, female, mean weight of 20 ± 5 kg, according to modifications in the Perini technique was performed. In the first phase, the aneurysm was confectioned with bovine pericardial patch. In the second phase, fifteen days later, the patency of the aneurysms was confirmed by Doppler ultrasonography. The described variables were aortic and aneurysm sac patency, incidence of rupture, morbidity and mortality. The statistical analysis program used was STATA v.8.Results:All animals survived to the procedures. Surgical mean time was 73 minutes. Aneurysm rupture, proximal or distal aortic thrombosis, visceral or legs ischemia weren't observed. Parietal thrombus formation was observed in all of the aneurysms, two of which (18%; IC 95% = 3.98 - 48.84) were occluded and nine (82%; IC 95% = 51.15 - 96.01) were patent.Conclusion:In this series, the modifications carried out in the technique related to the surgical approach, race, anesthesia, and imaging exams reproduced the experimental model, reducing its costs, without hindering the analysis of the variables. The satisfactory patency ratio allows the method to be used in experimental models for the development of vascular prostheses.

Abdominal aortic aneurysm model in swine with bovine pericardium patch

“…24 The bovine pericardium patch has also been described in swine models. 29 That study used hybrid pigs (crossbred Large White and Landrace), with a transperitoneal approach. Patency of the aorta and the aneurysm patch was confirmed with Doppler ultrasonography and the model of abdominal aortic aneurysm was not analyzed histologically.…”

Experimental Models in Abdominal Aortic Aneurysm

“…Complications like renal failure, intestinal perforation, sepsis, iliac artery thrombus may be seen in this model. Bovine pericardium is cheaper than synthetic materials because it can be acquired easily [42].…”