Experimental models for studying of skeletal muscles regeneration

Abstract

Striated muscles play an important role in the maintenance in the maintenance of locomotion, ventilation, mechanical protection, the inner organs support, a common system of energy exchange etc. Skeletal muscle tissue is exposed to various external factors which cause notable damage to skeletal tissue as a result of mechanical injury (contusion, compression, laceration), inflammation as an implication of infectious agents and autoimmune process, toxic effects of various chemical substances. Besides the external causes, genes' defects that code muscle protein components have influence on the muscles too. These defects lead to muscular dystrophies (Duchenne Becker muscular dystrophy, dysferlinopathy, calpainopathy etc.). In condition of serious injuries the cambial reserve by means of myosatellite cells and other myogenic cells usually does not provides hysto-and organotypic skeletal muscles regeneration. This fact determines development of new methods for induction of regeneration striated muscles and, in turn, requires amplification of using experimental models of muscles injury for studying regeneration of skeletal muscles The aim of this review is comparative description of experimental models applied for studying of skeletal muscles regeneration after its damage