Experimental Models of Type-I Diabetes

Bach, Jean‐François

doi:10.1159/000157028

Cited by 8 publications

(2 citation statements)

References 102 publications

(162 reference statements)

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“…Here we demonstrate the ability of CBD to significantly reduce the occurrence and delay the onset of overt diabetes in female NOD mice. NOD mice present with a clinical and immunological course very similar to human type 1 diabetes [27,28]. Therefore, these results raise the question of whether CBD could have a role in prevention of human type 1 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice

Weiss¹,

Zeira²,

Reich³

et al. 2006

Autoimmunity

184

132

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Cannabidinoids are components of the Cannabis sativa (marijuana) plant that have been shown capable of suppressing inflammation and various aspects of cell-mediated immunity. Cannabidiol (CBD), a non-psychoactive cannabidinoid has been previously shown by us to suppress cell-mediated autoimmune joint destruction in an animal model of rheumatoid arthritis. We now report that CBD treatment significantly reduces the incidence of diabetes in NOD mice from an incidence of 86% in non-treated control mice to an incidence of 30% in CBD-treated mice. CBD treatment also resulted in the significant reduction of plasma levels of the pro-inflammatory cytokines, IFN-g and TNF-a. Th1-associated cytokine production of in vitro activated T-cells and peritoneal macrophages was also significantly reduced in CBD-treated mice, whereas production of the Th2-associated cytokines, IL-4 and IL-10, was increased when compared to untreated control mice. Histological examination of the pancreatic islets of CBD-treated mice revealed significantly reduced insulitis. Our results indicate that CBD can inhibit and delay destructive insulitis and inflammatory Th1-associated cytokine production in NOD mice resulting in a decreased incidence of diabetes possibly through an immunomodulatory mechanism shifting the immune response from Th1 to Th2 dominance.

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Section: Discussionmentioning

confidence: 99%

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice

Weiss¹,

Zeira²,

Reich³

et al. 2006

Autoimmunity

184

132

View full text Add to dashboard Cite

show abstract

“…The involvement of T-cell-and macrophage-derived cytokines in IDDM pathogenesis remains the subject of intense investigation; conclusions were largely based on studies with the genetically IDDM-predisposed nonobese diabetic (NOD) mice and BioBreeding (BB) rats, animal models which display many of the characteristics of human type I diabetes (4), and have focused on direct cytotoxic and indirect immunomodulatory effects of cytokines in mediating ␤-cell destruction (58,82). Based on such studies, it was concluded that Th1 cytokines exacerbate, while Th2 cytokines protect from, IDDM (70,72).…”

mentioning

confidence: 99%