Experimental mucosal disease in cattle: Changes in the number of lymphocytes and plasma cells in the mucosa of the small and large intestine

Liebler, E. M.; Küsters, C.; Pohlenz, Joachim

doi:10.1016/s0165-2427(96)05715-7

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…The larger number of IgA+ plasma cells, along with the enhanced concentration of sIgA, found in the gut digesta of 1-wk-old SCB calves suggests an early endogenous production and release of sIgA at the mucosal surface. The IgA+ plasma cells were mainly distributed in the dome region of PP, the interfollicular area, the villi in ileum tissue, and the crypts in the colon section (Figure 3), as described by Liebler et al (1996) in 4-mo-old calves. It is important to note that the number of IgA+ plasma cells counted was very low at 1 wk of age (1-3 IgA+ plasma cells/ mm 2 ), which seems consistent with the data reported in 4-d-old healthy calves (2.6 IgA-containing cells/mm 2 ; Allen and Porter, 1975).…”

Section: Discussionmentioning

confidence: 70%

Early supplementation of Saccharomyces cerevisiae boulardii CNCM I-1079 in newborn dairy calves increases IgA production in the intestine at 1 week of age

Villot

Chen

Pedgerachny

et al. 2020

Journal of Dairy Science

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addition, the number of IgA-producing plasma cells were greater in both ileum (2.55 ± 0.40 cells/mm 2 ) and colon (3.03 ± 0.40 cells/mm 2 ) tissues for SCB calves compared with control (respectively 1.00 ± 0.40 and 0.60 ± 0.42 cells/mm 2 ). Endogenous IgA production in the gut of SCB calves was enhanced, which could make them less prone to pathogen intrusion. In addition, SCB calves had higher Lactobacillus and tended to have higher Faecalibacterium prausnitzii in the jejunum compared with control calves, which suggests that SCB supplementation during early-life gut colonization may have a positive effect in newborn calves. Direct SCB supplementation or the cross-talk between SCB and bacteria may be responsible for stimulating IgA production and may play a key role in shaping early colonization in the gut of newborn calves.

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Section: Discussionmentioning

confidence: 70%

Early supplementation of Saccharomyces cerevisiae boulardii CNCM I-1079 in newborn dairy calves increases IgA production in the intestine at 1 week of age

Villot

Chen

Pedgerachny

et al. 2020

Journal of Dairy Science

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“…Increased numbers of macrophages were seen in the mucosa of the oesophagus (Bielefeldt‐Ohmann, 1988). In the intestinal mucosa, numbers of plasma cells, CD8+ T‐lymphocytes and T‐lymphocytes were decreased and numbers of macrophages increased (Bielefeldt‐Ohmann, 1988; Liebler et al, 1996). Numbers of CD4+ T‐lymphocytes were increased in colonic and decreased in small intestinal mucosa (Liebler et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

“…In the intestinal mucosa, numbers of plasma cells, CD8+ T‐lymphocytes and T‐lymphocytes were decreased and numbers of macrophages increased (Bielefeldt‐Ohmann, 1988; Liebler et al, 1996). Numbers of CD4+ T‐lymphocytes were increased in colonic and decreased in small intestinal mucosa (Liebler et al, 1996). A relative increase of CD4+ and CD8+ T‐lymphocytes was found in the depleted lymphoid follicles of Peyer's patches (Liebler et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Changes in Distribution and Numbers of CD4+ and CD8+ T‐lymphocytes in Lymphoid Tissues and Intestinal Mucosa in the Early Phase of Experimentally Induced Early Onset Mucosal Disease in Cattle

Frink

Grummer²,

Pohlenz³

et al. 2002

Journal of Veterinary Medicine, Series B

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Mucosal disease (MD), one sequelae of bovine virus diarrhoea virus (BVDV) infection, causes severe lesions in lymphoid tissues and mucosal surfaces. Lesions are associated with the presence of cytopathogenic (cp) BVDV and initially characterized by apoptotic cell death. The objective of this investigation was to determine if this cell death is mediated only by the cp BVDV, which is known to induce apoptosis in cell culture or if immune-mediated host reactions might also contribute. Early onset MD was experimentally induced in calves by inoculation of persistently viremic calves with a closely related cp BVDV. Calves were euthanized in the early phase of infection between days 5 and 13 post-inoculation and tissues from tonsils, lymph nodes, Peyer's patches, jejunum and colon were collected. Presence of cp BVDV antigen was correlated with distribution of lymphocyte subpopulations in consecutive cryostat sections. In the lymphoid tissues, cp BVDV antigen was predominantly found in the lymphoid follicles. The increase of infected cells with time post-inoculation was paralleled by a decrease of B-lymphocytes and an increase of CD4+ T-lymphocytes. An increased number of CD8+ T-lymphocytes was seen in progressed lesions only. In the intestinal mucosa, initially multifocal, later diffuse infection with cp BVDV was accompanied by a multifocal or diffuse increase of CD4+ T-lymphocytes, respectively. Numbers of IgA+ plasma cells and CD8+ T-lymphocytes were decreased. The common change observed in lymphoid tissues and mucosa was the increase of CD4+ T-lymphocytes in sites with lesions. This might indicate a cell-mediated immune response to the cp BVDV. Besides their helper function to other cells of the immune system, activated CD4+ T-lymphocytes might also exert cytotoxic activity, induce apoptosis in target cells via Fas/Fas ligand binding and thus contribute to the severity of tissue lesions in MD.

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Pathogenesis

Liebler-Tenorio¹

2005

Bovine Viral Diarrhea Virus

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Experimental mucosal disease in cattle: Changes in the number of lymphocytes and plasma cells in the mucosa of the small and large intestine

Cited by 6 publications

References 25 publications

Early supplementation of Saccharomyces cerevisiae boulardii CNCM I-1079 in newborn dairy calves increases IgA production in the intestine at 1 week of age

Early supplementation of Saccharomyces cerevisiae boulardii CNCM I-1079 in newborn dairy calves increases IgA production in the intestine at 1 week of age

Changes in Distribution and Numbers of CD4+ and CD8+ T‐lymphocytes in Lymphoid Tissues and Intestinal Mucosa in the Early Phase of Experimentally Induced Early Onset Mucosal Disease in Cattle

Pathogenesis

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