Experimental mycotoxic nephropathy in pigs provoked by a mouldy diet containing ochratoxin A and fumonisin B1

Stoev, Stoycho D.; Gundasheva, D.; Zarkov, I.; Mircheva, T.; Zapryanova, D.; Denev, S.; Mitev, Yuri; Daskalov, H.; Dutton, Mike F.; Mwanza, Mulunda; Schneider, Yves‐Jacques

doi:10.1016/j.etp.2011.01.008

Cited by 70 publications

(91 citation statements)

References 40 publications

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“…interlobular oedema of non-inflammatory origin found in the peribronchial, peribronchiolar and perivascular areas of the lungs (Fazekas et al, 1998;Haschek et al, 1992). FB 1 has been reported to be a nephrotoxic for kidney (Bucci et al, 1998;Voss et al, 2001;Howard et al, 2001) and to provoke in vitro and in vivo degenerative and/or apoptotic damages in tubular epithelium of kidneys in rats or pigs (Dragan et al, 2001, Stoev et al, 2012, which was confirmed by the present study. FB 1 is also reported to impair protein synthesis in cells, which could lead to further degenerative changes in kidneys or liver, the target organs responsible for elimination or detoxification of mycotoxins (Abado-Becognee et al, 1998).…”

Section: Discussionsupporting

confidence: 88%

“…This process could be facilitated by the immunosuppressive effect of FB 1 on humoral immune response in pigs (Stoev et al, 2012). In this regard, a study of Ramos et al (2010) demonstrated that lung damages are much complicated in swine inoculated with PRRS virus, when the same are exposed additionally to FB 1 in the feed diet.…”

Section: Discussionmentioning

confidence: 99%

“…It was also found that FB 1 given at diet levels of 10 ppm, has immunosuppressive effect on humoral immune response in pigs (Stoev et al, 2012) and therefore can provoke some secondary bacterial infections, which arise in immunocompromised animals. In this regard, Oswald and collaborators observed a significant increase of intestinal colonization of pathogenic Escherichia coli in FB 1 -treated pigs (Oswald et al, 2003).…”

Section: Introductionmentioning

confidence: 97%

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Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocid a

Kovács

Pósa

Tuboly

et al. 2016

Research in Veterinary Science

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The possible interaction between Pasteurella multocida and the mycotoxin fumonisin B1 (FB1), recognised as one of the most often food/feed contaminant, was studied with the aim to evaluate whether and how FB1 can influence and/or complicate the development and severity of various pathological damages provoked by Pasteurella multocida in some internal organs of pigs. Heavier lung pathology was seen in pigs experimentally infected with Pasteurella multocida, when the same were exposed to 20 ppm dietary levels of fumonisin B 1 (FB 1 ) as was assessed by gross pathology, pathomorphological examinations, clinical biochemistry and some immunological investigations. The most typical damages in FB 1 treated pigs were the strong oedema in the lung and the slight oedema in the other internal organs and mild degenerative changes in the kidneys, whereas the typical pathomorphological findings in pigs infected with Pasteurella multocida was broncho-interstitial pneumonia. FB1 was found to aggravate pneumonic changes provoked by P. multocida in the cranial lobes of the lung and to complicate pneumonic damages with interstitial oedema in the lung. No macroscopic damages were observed in the pigs infected only with Pasteurella multocida. It can be concluded that the feed intake of FB1 in pigs may complicate or exacerbate the course of P. multocida serotype A infection.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocid a

Kovács

Pósa

Tuboly

et al. 2016

Research in Veterinary Science

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“…Studies with pigs about blood glucose levels after OTA toxication are contradictory (28)(29)(30)(31). When rabbits fed with 1 and 2 ppm OTA contaminated food, a decrease in blood glucose level observed after 3 weeks and at week 8, blood glucose level was half of the control group (32).…”

Section: Discussionmentioning

confidence: 99%

Diabetogenic Effects of Ochratoxin A in Female Rats

Mor

Sengul

Topsakal

et al. 2017

Preprint

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Abstract:In this study, diabetogenic effects of long term Ochratoxin A (OTA) administration in rats were investigated and its role in the etiology of diabetes mellitus (DM) was examined utilizing 42 female Wistar rats for these purposes. The rats were divided into 3 different study and control groups according to the duration of the OTA administration. Rats received 45 μg OTA daily in their feed for 6, 9 and 24 weeks study groups. Three control groups without any treatment were also used in the same periods. Blood and pancreatic tissue samples were collected during the necropsy at the end of 6, 9 and 24 weeks. Plasma values of insulin, glucagon and glucose in study and control groups were determined. Pancreatic lesions were evaluated by histopathological examination; then insulin and glucagon expression in these lesions were determined by immunohistochemical methods. Statistically significant decrease in insulin levels in contrast to increases in glucagon and glucose levels in blood were observed. Slight to moderate degeneration in Langerhans islet cells were observed at the histopathological examination in all OTA treated groups. Immunohistochemistry of pancreatic tissue revealed decreased insulin and increased glucagon expression. This study demonstrated that OTA may cause pancreatic damage in Langerhans islet and predispose rats to DM.

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“…It has been suggested that ochratoxin A and penicillic acid may both be involved in Balkan Endemic Nephropathy (Stoev, 2017;Stoev et al, 2001). Penicillium polonicum and Penicillium aurantiogriseum, both producing penicillic acid, verrucosidin and nephrotoxic glycopeptides, are often found in the Balkan countries, but Penicillium verrucosum, the main ochratoxin A producing Penicillium species in cereals, is found less often (MacGeorge and Mantle, 1990;Mantle, 1994;Mantle et al, 2010;Miljkovic et al, 2003;Stoev et al, 2010;Yeulet et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

Frisvad

2018

WMJ

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A very large number of filamentous fungi has been reported to produce the small lactone mycotoxins patulin, penicillic acid and moniliformin. Among the 167 reported fungal producers of patulin, only production by 29 species could be confirmed. Patulin is produced by 3 Aspergillus species, 3 Paecilomyces species, 22 Penicillium species from 7 sections of Penicillium, and one Xylaria species. Among 101 reported producers of penicillic acid, 48 species could produce this mycotoxin. Penicillic acid is produced by 23 species in section Aspergillus subgenus Circumdati section Circumdati, by Malbranchea aurantiaca and by 24 Penicillium species from 9 sections in Penicillium and one species that does not actually belong to Penicillium (P. megasporum). Among 40 reported producers of moniliformin, five species have been regarded as doubtful producers of this mycotoxin or are now regarded as taxonomic synonyms. Moniliformin is produced by 34 Fusarium species and one Penicillium species. All the accepted producers of patulin, penicillic acid and moniliformin were revised according to the new one fungus – one name nomenclatural system, and the most recently accepted taxonomy of the species.

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Experimental mycotoxic nephropathy in pigs provoked by a mouldy diet containing ochratoxin A and fumonisin B1

Cited by 70 publications

References 40 publications

Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocid a

Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocid a

Diabetogenic Effects of Ochratoxin A in Female Rats

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

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