Experimental Nephrotic Edema

The Plasma Proteins in Relation to Blood Hydration

“…An equal amount may be excreted in the urine of a nephrotic patient in the course of only 3 or 4 days. Removal of comparable quantities from dogs by plasmapheresis produces only transient serum protein deficiency (6,7). The effect of malnutrition on serum proteins appears to be confined entirely to the albumin fraction (8).…”

Plasma Protein and Plasma Colloid Osmotic Pressure in Pathological Conditions With Special Reference to the Occurrence of Edema 1

“…Frisch, Mendel and Peters (1929) also found a low blood protein coincident with edema in white rats fed a low protein diet. Further, Leiter (1931) by repeated plasmapheresis has been able to reduce the serum proteins in dogs, and found that edema appeared when the proteins had fallen to about 3 per cent or less. We had the opportunity to observe a case of nutritional edema (Fig.…”

The Significance of the Sodium and Potassium Content of Muscle Tissue and the Relation of the Amount of Edema Fluid in Muscle to the Level of Serum Protein in Experimental Nutritional Edema

“…These relations might also indicate whether sodium has any role in the production of edema other than that of being the chief base of plasma filtrate, this question having been often raised by the observed necessity of ingested sodium for the formation of experimental plasmapheresis edemas in dogs (1,2,3), and for the occurrence of nutritional (4) and nephrotic (5) edemas in man. A nutritional edema in white rats resulting from a protein-poor carrot diet (6,7) and shown to be accompanied by low serum proteins (8,9) was decided upon as a practical experimental setting for the problem.…”