Experimental obesity and diabetes reduce male fertility: Potential involvement of hypothalamic Kiss-1, pituitary nitric oxide, serum vaspin and visfatin

Abdel-Fadeil, Mahmoud R.; Allah, Eman S.H. Abd; Iraqy, Heba M.; Elgamal, Dalia A.; Abdel-Ghani, Mohammed Ali

doi:10.1016/j.pathophys.2019.02.001

Cited by 18 publications

(9 citation statements)

References 47 publications

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“…Testosterone and inhibin B were significantly decreased in the present study with administration of HFD, while FSH and E were significantly increased, compared to control. These findings are consistent with the studies of Jia et al [35] and Abdel-Fadeil et al [36] . Hormonal disturbances in the present study can be explained based on vitamin D deficiency (VD−) that occurred in this hyperlipidemic group.…”

Section: Discussionsupporting

confidence: 93%

The effect of lipid disturbance and vitamin D on the fertility in male albino rats

Hikal

Bayoumi

Ibrahim

et al. 2020

Journal of Recent Advances in Medicine

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Background: Vitamin D has multiple biological effects on male reproductive system. Vitamin D deficiency (VD−) and disturbance of lipid metabolism can induce changes in testicular hormone production and seminal parameters that relate to male infertility. Objective: To investigate the role of vitamin D and lipid metabolism on fertility in male albino rats . Methods:The study was performed on 60 male rats, divided into 6 groups; GI: control group, GII: orlistat group, GIII: orlistat and vitamin D group, GIV: hyperlipidemic group, GV: hyperlipidemic orlistat group and GVI: hyperlipidemic orlistat and vitamin D group. Serum total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c) and high density lipoprotein cholesterol (HDL-c), 25-hydroxyvitamin D (25(OHD), testosterone (T), inhibin B, follicle-stimulating hormone (FSH) and estradiol (E) levels were determined. Sperm count and viability were also analyzed .Results: Administration of orlistat in GII caused significant alterations of the serum lipid profile, compared to control group. There was interaction between dietary fat and VD− on serum 25 (OHD). A significant VD− was occurred in both GII and GIV, compared to GI. VD− in these groups consequently caused significant decrease in serum T, inhibin B, sperm count and viability and significant increase in FSH and E levels. Administration of orlistat in GV caused significant changes in serum lipid profile, a decrease in E, increase in 25(OHD) and inhibin B, compared to IV. On the other hand, administration of vitamin D with orlistat in GIII and GVI caused significant increase in HDL-c, 25(OHD), T, sperm count and viability and significant decrease in TC, TG, LDLc, FSH and E . Conclusion:Both hyperlipidemia and hypolipidemia were associated with vitamin D deficiency. Moreover, vitamin D has a positive potential effect on male fertility in either hyperlipidemic or hypolipidemic rats .

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Section: Discussionsupporting

confidence: 93%

The effect of lipid disturbance and vitamin D on the fertility in male albino rats

Hikal

Bayoumi

Ibrahim

et al. 2020

Journal of Recent Advances in Medicine

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“…Although visfatin has been demonstrated to be produced by human spermatozoa, notably the immature ones [137], and its levels are 100 times higher in seminal fluid than in blood plasma [139], no consistent data are available regarding its role in male reproductive disorders. In a very recent study carried out in obese and diabetic rats, plasma visfatin was negatively correlated with semen quality parameters, testosterone and LH levels and degenerative changes in the testis, suggesting that this adipokine may play a role in the physiopathology of male infertility associated with obesity and diabetes [281]. It must, however, be kept in mind that several authors failed to find any significant correlation between seminal and plasma visfatin and sperm parameters in humans [139].…”

Section: Adipokines and Male Reproductive Pathologiesmentioning

confidence: 99%

Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models

Estienne

Bongrani

Reverchon

et al. 2019

IJMS

134

112

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It is well known that adipokines are endocrine factors that are mainly secreted by white adipose tissue. Their central role in energy metabolism is currently accepted. More recently, their involvement in fertility regulation and the development of some reproductive disorders has been suggested. Data concerning the role of leptin and adiponectin, the two most studied adipokines, in the control of the reproductive axis are consistent. In recent years, interest has grown about some novel adipokines, chemerin, visfatin, resistin and apelin, which have been found to be strongly associated with obesity and insulin-resistance. Here, we will review their expression and role in male and female reproduction in humans and animal models. According to accumulating evidence, they could regulate the secretion of GnRH (Gonadotropin-Releasing Hormone), gonadotropins and steroids. Furthermore, their expression and that of their receptors (if known), has been demonstrated in the human and animal hypothalamo-pituitary-gonadal axis. Like leptin and adiponectin, these novel adipokines could thus represent metabolic sensors that are able to regulate reproductive functions according to energy balance changes. Therefore, after investigating their role in normal fertility, we will also discuss their possible involvement in some reproductive troubles known to be associated with features of metabolic syndrome, such as polycystic ovary syndrome, gestational diabetes mellitus, preeclampsia and intra-uterine growth retardation in women, and sperm abnormalities and testicular pathologies in men.

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“…The data describing vaspin function in ovarian and testicular cells will be useful to regulate agricultural species, including pigs breeding. Finally, some authors indicated vaspin as a clinical predictor and novel biomarker of many pathologies, including GDM, PCOS [13], MetS [89], hypo-and hyperthyroidism [76], MTC [106], and semen quality [86].…”

Section: Perspectivesmentioning

confidence: 99%

“…Moreover, the androgen receptor inhibitor flutamide decreased vaspin and GRP78 mRNA and protein expression in the testes [ 85 ], linking this adipokine with steroidogenesis ( Figure 2 ). Notably, serum vaspin levels were negatively correlated with T and LH, as well as with semen quality parameters [ 86 ], indicating the inhibitory effect of vaspin on endocrine testes function. There are no data about vaspin function in the testes or its connection with testis pathologies; nevertheless, the expression of vaspin in the testes and its correlation with hormones indicate that vaspin regulates testis function, similar to other adipokines.…”

Section: Vaspin Expression and Action In The Testesmentioning

confidence: 99%

Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells

Kurowska

Mlyczyńska

Dawid

et al. 2021

Cells

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Proper functioning of the body depends on hormonal homeostasis. White adipose tissue is now known as an endocrine organ due to the secretion of multiple molecules called adipokines. These proteins exert direct effects on whole body functions, including lipid metabolism, angiogenesis, inflammation, and reproduction, whereas changes in their level are linked with pathological events, such as infertility, diabetes, and increased food intake. Vaspin-visceral adipose tissue-derived serine protease inhibitor, or SERPINA12 according to serpin nomenclature, is an adipokine discovered in 2005 that is connected to the development of insulin resistance, obesity, and inflammation. A significantly higher amount of vaspin was observed in obese patients. The objective of this review was to summarize the latest findings about vaspin expression and action in endocrine tissues, such as the hypothalamus, pituitary gland, adipose tissue, thyroid, ovary, placenta, and testis, as well as discuss the link between vaspin and pathologies connected with hormonal imbalance.

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Experimental obesity and diabetes reduce male fertility: Potential involvement of hypothalamic Kiss-1, pituitary nitric oxide, serum vaspin and visfatin

Cited by 18 publications

References 47 publications

The effect of lipid disturbance and vitamin D on the fertility in male albino rats

The effect of lipid disturbance and vitamin D on the fertility in male albino rats

Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models

Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells

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