Experimental otoacoustic emission and auditory brainstem response changes by stellate ganglion blockage in rat

Fırat, Yezdan; Kızılay, Ahmet; Özturan, Orhan; Ekici, Nur Yucel

doi:10.1016/j.amjoto.2008.02.001

Cited by 5 publications

(6 citation statements)

References 31 publications

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“…BAEP threshold evaluation under various experimental conditions can be used to evaluate ototoxicity of compounds (Husain, et al, 2004; Meli, et al, 2006; Giordano, et al, 2006; Firat, et al, 2008). More information about which region of the peripheral or central nervous system is functioning abnormally can be determined through analysis of the amplitudes and latencies of the waveforms produced.…”

Section: Discussionmentioning

confidence: 99%

Profile of minocycline neuroprotection in bilirubin-induced auditory system dysfunction

et al. 2011

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Excessive hyperbilirubinemia in human neonates can cause permanent dysfunction of the auditory system, as assessed with brainstem auditory evoked potentials (BAEPs). Jaundiced Gunn rat pups (jjs) exhibit similar BAEP abnormalities as hyperbilirubinemic neonates. Sulfadimethoxine (sulfa) administration to jjs, which displaces bilirubin from serum albumin into tissues including brain, exacerbates acute toxicity. Minocycline administered prior to sulfa in jjs protects against BAEP abnormalities. This study evaluates the neuroprotective capabilities of minocycline HCl (50mg/kg) administered 30 or 120min after sulfa (200mg/kg) in 16 day old jjs. BAEPs are recorded at 6 or 24hr post-sulfa. Abnormal BAEP waves exhibit increased latency and decreased amplitude. The sulfa/saline treated jjs exhibited a significantly increased interwave interval between waves I and II (I–II IWI) and significantly decreased amplitudes of waves II and III compared to the saline/saline jjs. The minocycline 30min post-sulfa (sulfa/mino +30) group was not significantly different from the saline/saline control group, indicating neuroprotection. The minocycline 120min post-sulfa (sulfa/mino+120) group had a significantly decreased amplitude of wave III at both 6 and 24hr. These studies indicate that minocycline has a graded neuroprotective effect when administered after acute bilirubin neurotoxicity.

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Section: Discussionmentioning

confidence: 99%

Profile of minocycline neuroprotection in bilirubin-induced auditory system dysfunction

et al. 2011

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“…The results of this study may explain the therapeutic benefits of SGB for some diseases such as sensorineural hearing loss and ischemic optic neuropathy. Firat et al 33 demonstrated that hearing, especially at higher frequencies, responded to increased cochlear blood flow after SGB and that patients with cochlear hearing disorders, particularly in sudden sensorineural hearing loss, responded to SGB treatment. The increase in signal intensity we observed for the ECA, STA, and maxillary artery (and potentially its branches, such as the anterior tympanic artery, which supplies blood to the adjacent areas of the cochlea and inner ear) may explain some of the benefits observed by others for SGB for hearing loss of unknown etiology.…”

Section: Discussionmentioning

confidence: 99%

Effect of Stellate Ganglion Block on the Cerebrovascular System

Kang

Oh²,

Chung

et al. 2010

Anesthesiology

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“…Wangemann and Wonneberger [2005] reported that sympathetic innervation led to vasoconstriction of the main blood supply of the cochlea in guinea pigs and gerbils. Conversely, SG block improved the hearing parameters of normal CBF in rats [Firat et al, 2008]. The decrease in CBF was significantly greater following propofol infusion with topical epinephrine compared to that following control treatment, and the threshold was increased [Jang et al, 2016].…”

Section: Sympathetic Activity and Peripheral Auditory Systemmentioning

confidence: 92%

“…Angiotensin receptor antagonist application protects against noise-induced microcirculatory ischemia and auditory sensitivity [Kellerhals, 1972;Miller et al, 1983;Hatch et al, 1991;Goldwyn et al, 1998]. Furthermore, SG blockade im-proved auditory parameters in rats with normal CBF, suggesting that SG blockade is a potential treatment option for vascular pathologies of the cochlea [Firat et al, 2008].…”

Section: Noise-induced Hearing Lossmentioning

confidence: 99%

Sympathetic Nervous System Regulation of Auditory Function

Tian¹,

Zha²

2021

Audiol Neurotol

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Background: The auditory system processes how we hear and understand sounds within the environment. It comprises both peripheral and central structures. Sympathetic nervous system projections are present throughout the auditory system. The function of sympathetic fibers in the cochlea has not been studied extensively due to the limited number of direct projections in the auditory system. Nevertheless, research on adrenergic and noradrenergic regulation of the cochlea and central auditory system is growing. With the rapid development of neuroscience, auditory central regulation is an extant topic of focus in research on hearing. Summary: As such, understanding sympathetic nervous system regulation of auditory function is a growing topic of interest. Herein, we review the distribution and putative physiological and pathological roles of sympathetic nervous system projections in hearing. Key Messages: In the peripheral auditory system, the sympathetic nervous system regulates cochlear blood flow, modulates cochlear efferent fibers, affects hair cells, and influences the habenula region. In central auditory pathways, norepinephrine is essential for plasticity in the auditory cortex and affects auditory cortex activity. In pathological states, the sympathetic nervous system is associated with many hearing disorders. The mechanisms and pathways of sympathetic nervous system modulation of auditory function is still valuable for us to research and discuss.

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Experimental otoacoustic emission and auditory brainstem response changes by stellate ganglion blockage in rat

Cited by 5 publications

References 31 publications

Profile of minocycline neuroprotection in bilirubin-induced auditory system dysfunction

Profile of minocycline neuroprotection in bilirubin-induced auditory system dysfunction

Effect of Stellate Ganglion Block on the Cerebrovascular System

Sympathetic Nervous System Regulation of Auditory Function

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