Experimental Ovine Model of Primary Venous Valve Incompetence: A Pilot Study

Park, Won Kyu; Pavčnik, Dušan; Shirley, Brad; Lü, Wei; Uchida, Barry T.; Yin, Qiang; Hoppe, Hanno; Dück, M; Liu, Long; Keller, Frederick S.; Rösch, Josef

doi:10.1016/j.jvir.2007.06.001

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…29 For their experimental animal work they used an ovine JV due to anatomical and functional similarities of the sheep JV with the human femoral vein. 23,[31][32][33]37 The BVVs were designed to demonstrate several potential advantages for treatment of CDVI. The primary advantage of the BVV is the design of the cusp, which consists of a free edge of SIS and the native vein wall lined with ECs.…”

Section: Z-stent-based Venous Valvesmentioning

confidence: 99%

Percutaneous management of chronic deep venous reflux: review of experimental work and early clinical experience with bioprosthetic valve

et al. 2008

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Lower extremity chronic deep venous insufficiency (CDVI) is common and remains a major health problem worldwide. Selected patients benefited from direct deep vein valve surgical repair or valve transplantation. A major limitation of this approach is that most of the patients are not candidates for these procedures due to obstructions or residual thrombus throughout the vein. The past 15 years have witnessed experimental efforts at catheter-based management of CDVI. This review describes the initial designs and experimental evolution of a mechanical and bioprosthetic venous valve that can be implanted by using a transcatheter technique. These valves consisted of single, double, or triple cusp leaflets made of synthetic or biological materials attached to a carrier or frame. All described devices for percutaneous transcatheter valve placement rely on some form of a vascular stent for valve attachment.

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Section: Z-stent-based Venous Valvesmentioning

confidence: 99%

Percutaneous management of chronic deep venous reflux: review of experimental work and early clinical experience with bioprosthetic valve

et al. 2008

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“…2006). Heart pathology has also been an area in which sheep have been employed as model animals, in the examination of pathological processes themselves (Park et al. 2007) as well as in the investigation of artificial replacement devices (Ozaki et al.…”

Section: Large Animal Modelsmentioning

confidence: 99%

“…The pregnant sheep has been found a suitable model for foetal or paediatric invasive procedures (Dreyfus et al 1997;Mortell et al 2006). Heart pathology has also been an area in which sheep have been employed as model animals, in the examination of pathological processes themselves (Park et al 2007) as well as in the investigation of artificial replacement devices (Ozaki et al 2004;Murphy et al 2007).…”

Section: Sheep (Ovis Aries)mentioning

confidence: 99%

Domestic Animal Models for Biomedical Research

Bähr

Wolf

2012

Reprod Domestic Animals

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Contents Experimental animals in biomedical research provide insights into disease mechanisms and models for determining the efficacy and safety of new therapies and for discovery of corresponding biomarkers. Although mouse and rat models are most widely used, observations in these species cannot always be faithfully extrapolated to human patients. Thus, a number of domestic species are additionally used in specific disease areas. This review summarizes the most important applications of domestic animal models and emphasizes the new possibilities genetic tailoring of disease models, specifically in pigs, provides.

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