Experimental Partial Ureteric Obstruction in Newborn Rats. IV. Do the Morphological Effects Progress Continuously?

Claesson, Gösta; Josephson, Staffan; Robertson, Bengt

doi:10.1016/s0022-5347(17)51764-4

Cited by 45 publications

(25 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no con vincing evidence of any change with time. The hypertro phy was moderate, but comparable to what we observed with permanent obstruction: the contralateral weight was 9% above controls after 6 weeks [16], 6% after 9 weeks [17,18] and 13% after 1 year [ 19], Irreversibility is one explanation for persistence of con tralateral hypertrophy; its existence has, however, been debated. In normal rats with a normal, third transplant kidney, both absence [7,20] and presence [6,9] of reversal have been observed.…”

Section: Discussionsupporting

confidence: 84%

Experimental Partial Ureteric Obstruction in Newborn Rats

Josephson

Larsson²

1996

Urol Int

Self Cite

View full text Add to dashboard Cite

In unilateral kidney disease, it has been suggested that the ipsilateral state could be estimated by measuring contralateral kidney size; thus, a contralateral increase should reflect an ipsilateral impairment and vice versa. This could easily be performed using ultrasound. In our experiments with partial obstruction of one ureter (created in 1- to 3-day-old rats), a consistent and stable contralateral kidney hypertrophy occurred. However, after unobstruction, the hypertrophy persisted for at least a 6-week observation period, despite the disappearance of hydronephrosis and presence of a normal weight of the ipsilateral kidney. This would undeniably hamper the diagnostic utility of kidney size determination. To find out whether or not the hypertrophy ever disappears, we have performed studies after 6, 9 and 15 weeks. (1) The weight of the unobstructed kidney was found normal except after 15 weeks. The microstruc-ture was normal except for some minor changes. (2) The contralateral kidney was significantly heavier than controls at all checkpoints (+10, +13 and +6%). No significant regression occurred over the observation period. (3) Furthermore, the weights of both kidneys were interrelated, but the slopes were positive, thus, the contralateral hypertrophy was not greater the lesser the ipsilateral kidney weight. The reasons for the persistence of contralateral hypertrophy are discussed. The present findings do not support the idea of documenting improvement by measuring contralateral kidney size. However, repeat studies in the same individual may prove to be more sensitive and are therefore recommended until further notice.

show abstract

Section: Discussionsupporting

confidence: 84%

Experimental Partial Ureteric Obstruction in Newborn Rats

Josephson

Larsson²

1996

Urol Int

Self Cite

View full text Add to dashboard Cite

show abstract

“…But many studies using the same model have revealed different results. Some differences such as fibrosis in the renal pelvis and deformation in the renal papilla have been reported in the second week of partial unilateral ureteral obstruction (Claesson et al, 1983). On the contrary, dilatation, local inflammatory response and degeneration in collective and corrugated tubules are not remarkable.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of hydronephrotic kidney parenchymal density by non-contrast multislice computed tomography

Yildirim¹,

Açıkgöz²,

Danacı³

et al. 2012

jecm

View full text Add to dashboard Cite

ÖZETUzun süren üreteral obstrüksiyonun böbrek fonksiyon kaybına neden olduğu iyi bilinmektedir. Üriner sistem taşına bağlı herhangi bir obstrüksiyonun kontrastsız çok kesitli bilgisayarlı tomografi (KÇKBT) ile belirlenmesi tedavi zamanlaması hakkında karar vermek açısından çok önemlidir. Çalişmamızda deneysel hidronefroz oluşturulan ratlarda renal parankim dansitesinde meydana gelen değişiklikler KÇKBT ile değerlendirildi. Bu çalışmada sol üreterlerinde total veya parsiyel obstrüksiyon oluşturulmuş SpraqueDawley ratların böbrek parankim dansiteleri deneyin 1.,3. ve 30. günlerinde KÇKBT ile değerlendirilerek, sham ve kontrol grubu ratların böbrek parankim dansiteleri ile karşılaştırıldı. Parsiyel üreteral obstrüksiyon oluşturulmuş ratların böbrek parankim dansiteleri ile kontrol grubunun böbrek parankim dansiteleri arasında anlamlı bir fark olmadığı saptandı. Bununla birlikte total üreteral obstrüksiyon oluşturulmuş ratların böbrek parankim dansitelerinin karşı taraf böbrekleri ve kontrol grubu ile karşılaştırıldığında anlamlı olarak azaldığı saptandı. Böbrek üst, orta ve alt segmentlerinin ortalama dansite değerleri benzerdi. Elde edilen bu bulguların insanlarda üreter obstrüksiyonun sonuçlarının değerlendirilmesinde yararlı olabileceğini düşünmekteyiz. KÇKBT değerlendirilmesinde renal parankim dansitesinin azalması renal parankimal hasarın bir göstergesi olabilir.J. Exp. Clin. Med., 2012; 29:215-220 It is well known that a prolonged ureteral obstruction leads to function loss of the congested kidney. Determining whether kidney stones cause any obstruction by noncontrast multislice CT is crucial for deciding about the timing of treatment. In our study we evaluated by Non-Contrast Multislice Computed Tomography (NCMSCT) detectable reliable changes of the density of the renal parenchyma in rats with artificial hydronephrosis. We made total or partial obstruction to left ureters of Spraque-Dawley rats, and applied sham operation to control groups. Using NCMSCT we measured the renal average parenchyma densities in the first, third and thirteenth days of operation. There was no significant difference between the parenchyma density of partial obstructed group and control group. However the parenchyma density in totally obsructed kidneys has significantly decreased compared to the contralateral kidneys and control group. In this group the duration of the obstruction correlated with signifıcantly decreased parenchyma density. The average density values of the upper, middle and lower renal segments were similar. We assume that our results can be useful in the evaluation of the consequences of the ureteral obstruction. The decrease of the parenchyma density evaluated in NCMSCT could be an important indicator of the renal parenchymal damages.

show abstract

“…The disproportion between the immature and mature layers of the cortex is better explained by a delay in the postnatal differention. Such a disturbance would explain why, in chronic partial ureteric obstruc tion, the parenchymal weight is reduced only in rats obstructed neonatally [5,9] but not in rats obstructed at the age of 3-6 weeks [10-12].…”

Section: Discussionmentioning

confidence: 99%

“…This may explain why the parenchymal weight reduction, develop ing within 2 weeks after creation of ureteric obstruction in newborn rats, does not progress after that [5] and why this weight reduction is avoided only if the obstruction is released already within the first few days [6], The impor tance of the first obstructive period is supported by clin ical observations in children with hydronephrosis un dergoing surgical treatment; following pyeloplasty, the previously obstructed kidney grows but remains in the same weight 'channel' as before [13].…”

Section: Discussionmentioning

confidence: 99%

“…During the first 4-5 days, the glomeruli in the subcapsular layer are in the S stage [1], resembling the human fetal kidney in the last trimester [2], On the basis of autopsy studies in human fetuses, Osathanondh and Potter [3] postulated that immature nephrons are particulary susceptible to obstructive nephropathy. These authors found that par tial obstruction of the urethra caused dysplastic renal changes, whereas partial obstruction of the ureter was associated with but little renal change, possibly reflecting that, in the latter case, the obstruction is usually less severe and occurs at a later stage of fetal develop ment [4], Our own previous studies indicate that the influence of partial ureteric obstruction on the neonatal rat kidney is particularly evident during the first few days after birth [5,6], i.e. at a stage when the subcapsular nephrons are still immature [1].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Experimental Obstructive Hydronephrosis on the Immature Nephrons in Newborn Rats

Josephson

Robertson²,

Rodensjö³

1989

Urol Int

Self Cite

View full text Add to dashboard Cite

Partial obstruction of the left ureter was created in rats less than 36 h of age and its effects were studied at the age of 2–6 days. A considerable hydronephrosis with distension of the kidney developed within 1 day after obstruction, but there was no parenchymal weight reduction. The thickness of the mature, inner cortical layer was significantly decreased, suggesting a delay in the differention of the cortex. The parenchymal weight reduction, previously documented in our laboratory after long-standing ureteric obstruction, may thus be caused by a retardation of renal growth, which is never caught up, rather than by an atrophy of renal parenchyma or other destructive tissue lesions.

show abstract

Experimental Partial Ureteric Obstruction in Newborn Rats. IV. Do the Morphological Effects Progress Continuously?

Cited by 45 publications

References 11 publications

Experimental Partial Ureteric Obstruction in Newborn Rats

Experimental Partial Ureteric Obstruction in Newborn Rats

Evaluation of hydronephrotic kidney parenchymal density by non-contrast multislice computed tomography

Effects of Experimental Obstructive Hydronephrosis on the Immature Nephrons in Newborn Rats

Contact Info

Product

Resources

About