Experimental pastes containing niobophosphate and 45S5 bioactive glasses for treatment of dentin hypersensitivity: dentin permeability and tubule obliteration

Freitas, Samantha Ariadne Alves de; Ferreira, Paulo Vítor Campos; Carvalho, Edilausson Moreno; Aldaz, Mayra Alejandra Núñez; Loguércio, Alessandro Dourado; Grazziotin‐Soares, Renata; Carvalho, Ceci Nunes; Pereira, Adriana de Fátima Vasconcelos; Bauer, José

doi:10.1007/s00784-022-04595-7

Cited by 3 publications

(1 citation statement)

References 50 publications

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“…However, commonly used granule-like or bulk scaffolds exhibited operational inconvenience. More recently, bone cements, bone putties [ 2–4 ], 3D printing scaffolds [ 5–9 ] and hydrogels [ 10–13 ], which focused on providing shape matching property, have gained wide interests. Although bioactive bone cements and putties products like NovaBone Putty ® have been widely used in clinic, inorganic particles in this system hardly bond with each other and with the liquid phase, which will risk collapse and reduction of the reconstruction effect.…”

Section: Introductionmentioning

confidence: 99%

Phosphoserine enhanced Cu-doped bioactive glass dynamic dual-network hydrogel for craniofacial bone defect repair

Liu

Wang

Luo

et al. 2023

Regenerative Biomaterials

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Flexible hydrogels containing various osteogenic inorganic constituents, which can accommodate complicated shape variations, are considered as ideal grafts for craniofacial bone defect reconstruction. However, in most hybrid hydrogels, poor interaction between the polymer network and particles has detrimental effects on hydrogel rheological and structural properties, clinical manipulation and repair efficacy. In this article, we designed and prepared a series of hyaluronic acid composite hydrogel containing Cu doped bioactive glass (CuBG) and phosphoserine (PS), in which hyaluronic acid was modified by methacrylate groups and phenylboronic acid groups to form a double crosslinked network. PS acted as an interaction bridge of CuBG particles and HAMA-PBA network to improve the mechanical properties of the composite hydrogels. The CuBG/PS hydrogels exhibited suitable rheological properties (injectable, self-healing, shape-adaptable), bone tissue integrating ability and anti-bacterial property. Meanwhile, we found that CuBG and PS have synergistic effect on improving osteogenic efficiency both in vitro and in vivo, particularly when the ratio of CuBG to PS is lower than 3 (9CB/3 PS). This work provided a versatile and scalable approach to enhanced the interaction within inorganic particles and polymer network in hydrogels without extra modification on components.

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Section: Introductionmentioning

confidence: 99%

Phosphoserine enhanced Cu-doped bioactive glass dynamic dual-network hydrogel for craniofacial bone defect repair

Liu

Wang

Luo

et al. 2023

Regenerative Biomaterials

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A novel mussel-inspired desensitizer based on radial mesoporous bioactive nanoglass for the treatment of dentin exposure: An in vitro study

Huang,

Jia,

Zhu

et al. 2024

Journal of the Mechanical Behavior of Biomedical Materials

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Non-collagenous protein analog-induced biomimetic mineralization strategy to restore the dentin interface

Chen,

Xie,

et al. 2024

Biomed. Phys. Eng. Express

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Dentin biomineralization is a gene-regulated, cytokine-mediated, and programmed process by mineralized cells to form highly ordered hydroxyapatite (HAP) crystals encapsulating dentin matrix, ultimately building a stable dentin interface. Repairing dentin damage caused by irreversible demineralization has been a challenge in dental regenerative medicine due to dentin’s limited biomineralization ability. It is well established that non-collagenous proteins (NCPs)-collagen interactions and NCPs-crystal interactions influence the nucleation, deposition, arrangement, and assembly of HAP crystals during the biomineralization process. Inspired by this process, NCP analogs can be used as a biomimetic template to stabilize the intermediate mineral phases of biomineralization to achieve collagen fibrils’ hierarchical mineralization in dentin. In addition, specific functional groups can be introduced to achieve antimicrobial, anti-enzymatic, and cross-linking functions to restore the microstructure and mechanical properties of demineralized dentin. Therefore, the design and development of NCP analogs are currently a hot topic in dentin biomimetic restorations. However, most existing reviews have only focused on the mineralization effect of NCP analogs and have rarely summarized their additional functions and applications at the dentin interface. This review first summarizes the basic principles of dentin biomineralization and biomimetic mineralization and then focuses on the common classifications of NCP analogs and newly introduced functional properties. It finally discusses the applications and limitations of NCP analogs in dentin interface, providing a theoretical basis for applying NCP analogs in the minimally invasive treatment of demineralized dentin.

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Experimental pastes containing niobophosphate and 45S5 bioactive glasses for treatment of dentin hypersensitivity: dentin permeability and tubule obliteration

Cited by 3 publications

References 50 publications

Phosphoserine enhanced Cu-doped bioactive glass dynamic dual-network hydrogel for craniofacial bone defect repair

Phosphoserine enhanced Cu-doped bioactive glass dynamic dual-network hydrogel for craniofacial bone defect repair

A novel mussel-inspired desensitizer based on radial mesoporous bioactive nanoglass for the treatment of dentin exposure: An in vitro study

Non-collagenous protein analog-induced biomimetic mineralization strategy to restore the dentin interface

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