Experimental peri-implant mucositis around titanium and zirconia implants in comparison to a natural tooth: part 1—host-derived immunological parameters

Clever, Kim; Schlegel, Karl Andreas; Kniha, Heinz; Conrads, Georg; Rink, Lothar; Modabber, Ali; Hölzle, Frank; Kniha, Kristian

doi:10.1016/j.ijom.2018.10.018

Cited by 12 publications

(8 citation statements)

References 26 publications

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“…However, analysis for TNFα values presented no significant differences within each subgroup. Furthermore, in an in vivo study in humans, titanium and zirconia implants performed better than their natural counterparts in terms of IL-6 and TNFα 25 . By contrast, another mucositis study suggested that the implant group had a significantly higher expression of IL-6 than the healthy tooth group 39 .…”

Section: Discussionmentioning

confidence: 92%

“…Before the sample collection, under sterile conditions, the paper points with color-coded ends were cut off at the lowest colored end, according to the procedure of a previously published study 25 . Afterwards, sterile paper points were inserted at the deepest probing pocket depth around each implant (either zirconia or titanium) or natural tooth (second molar of one side), which was the deepest side at baseline measurements (VDW, 29 mm, ISO 15, Taper.04, Munich, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…These studies only included titanium implants. Whether modern zirconium dioxide implants have advantages due to other material properties, such as a reduced tendency to mucositis, remains unclear 25 , 26 . It is of great importance to learn more about modern zirconia implants, especially with regard to the material properties and the resulting individual peri-implant inflammation risk.…”

Section: Introductionmentioning

confidence: 99%

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Host inflammatory response and clinical parameters around implants in a rat model using systemic alendronate and zoledronate acid drug administrations

Kniha

Rink

Wolf

et al. 2022

Sci Rep

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Implant outcomes in comparison to a natural tooth in a rat model using systemic alendronate and zoledronate acid drug administrations were assessed. Fifty-four Sprague–Dawley rats were randomly allocated into two experimental groups (drug application of zoledronic acid; 0.04 mg/kg intravenously once a week and alendronic acid; 0.2 mg/kg subcutaneously five times a week) and one control group with 18 animals in each group. Drug delivery was conducted for a period of 4 months. After 4 weeks either a zirconia or a titanium implant was immediately inserted in the socket of the first molar of the upper jaw. In vivo investigations included host inflammatory parameters and the implant survival and success rates for up to 3 months. Material incompatibilities against titanium and zirconia nanoparticles were evaluated in vitro after stimulation of rat spleen cells. In vivo, IL-6 release around titanium implants demonstrated significantly higher values in the control group (p = 0.02) when compared to the zoledronic acid group. Around the natural tooth without drug administration, the control group showed higher IL-6 values compared with the alendronic acid group (p = 0.01). In vitro, only lipopolysaccharide and not the implant’s nanoparticles stimulated significant IL-6 and TNFα production. In terms of the primary aim of in vivo and in vitro IL-6 and TNFα measurements, no implant material was superior to the other. No significant in vitro stimulation of rat spleen cells was detected with respect to titanium oxide and zirconium oxide nanoparticles.

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Section: Discussionmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Host inflammatory response and clinical parameters around implants in a rat model using systemic alendronate and zoledronate acid drug administrations

Kniha

Rink

Wolf

et al. 2022

Sci Rep

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“…Clever et al showed that the soft tissue around titanium implants clinically developed a stronger inflammatory response to experimental plaque accumulation compared with that around zirconia implants. 15,16 This in vivo rat primarily aimed to evaluate changes between two different implant materials regarding the extent of bone loss and jaw necrosis with micro-computed tomography (μCT) images following dental implantation under a systemic bisphosphonate delivery. In this study design, zirconia implants were compared with titanium implants, which were immediately inserted after tooth extraction.…”

Section: Introductionmentioning

confidence: 99%

“…Clever et al. showed that the soft tissue around titanium implants clinically developed a stronger inflammatory response to experimental plaque accumulation compared with that around zirconia implants 15,16 …”

Section: Introductionmentioning

confidence: 99%

Microstructural volumetric analysis of the jaw following dental implantation under systemic bisphosphonate delivery: An in vivo and ex vivo rat study

Kniha

Peters

Magnuska

et al. 2020

Journal of Periodontology

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Background: Because of bisphosphonate medication, dental implantation with a subsequent infection poses a relevant risk factor to suffer from medicationrelated osteonecrosis of the jaw. This rat study evaluated different implant materials under systemic bisphosphonate delivery using micro-computed tomography (μCT) images. Methods: Fifty-four rats were randomly allocated into a control group 1, test group 2 with intravenous drug application of zoledronic acid and test group 3 with a subcutaneous application of alendronic acid. After 4 weeks of drug delivery, the first molar on each side of the upper jaw was extracted, and either a zirconia or a titanium implant was immediately inserted. Radiological examinations at four timepoints before the operation, 1 week later, 6 weeks later and after 12 weeks of follow up included μCT measurements of the in vivo peri-implant bone loss. μCT measurements of the ex vivo peri-implant bony structure after 12 weeks follow-up covered the bone mineral density, -volume, -trabecular thickness and -separation. Results: Both test groups showed a significant increase in bone loss over time (P < 0.05). The clinical observations of exposed bone revealed that most cases occurred under alendronic acid delivery. Exposed bone was recorded only in the test groups around both titanium and zirconia implants. Regarding the periimplant bony structure, no significant differences were found between both materials. Conclusions: Systemic bisphosphonate delivery led to increased peri-implant bone loss over time after immediate implant insertion. In terms of bone resorption and bone quality parameters, no implant material was superior to the other.

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Implant Materials and Surfaces to Minimizing Biofilm Formation and Peri-implantitis

Petrini

Radunović

Pilato

et al. 2020

Advances in Dental Implantology Using Nanomaterials and Allied Technology Applications

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Experimental peri-implant mucositis around titanium and zirconia implants in comparison to a natural tooth: part 1—host-derived immunological parameters

Cited by 12 publications

References 26 publications

Host inflammatory response and clinical parameters around implants in a rat model using systemic alendronate and zoledronate acid drug administrations

Host inflammatory response and clinical parameters around implants in a rat model using systemic alendronate and zoledronate acid drug administrations

Microstructural volumetric analysis of the jaw following dental implantation under systemic bisphosphonate delivery: An in vivo and ex vivo rat study

Implant Materials and Surfaces to Minimizing Biofilm Formation and Peri-implantitis

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