Experimental Pregnancy-Associated Hypertension in the Pregnant Rabbit

Maternal Placental Blood Flow Is Reduced in Proportion to Reduction in Uterine Driving Pressure

“…One study has shown that long-term constriction of the lower aorta of rabbits during pregnancy results in maternal hypertension (7), but this has not been a consistent finding (27). If maternal placental blood flow is strongly dependent on maternal arterial blood pressure, and if there is some mechanism for sensing inadequate placental flow, then a teleologically appropriate response to increase uteroplacental blood flow would be to increase maternal blood pressure.…”

Gut Microbiota Dysbiosis and Increased NLRP3 Levels in Patients with Pregnancy-Induced Hypertension

“…NLRP3 can be Fig. 4 The cytokines levels in the serum and placenta tissues have significant difference between the PIH group and the control group, and the correlation coefficients between gut microbiota and cytokines in the two groups. A The inflammatory cytokines levels in serum.…”

“…Hypertension and complication are the most common medical problem in pregnancy, affecting up to 10% of pregnant women, causing high incidence rate and mortality of pregnant and parturient [3]. In the USA, 15% of maternal mortality is caused by PIH and its complications, which is the second leading cause of death in this population [4]. Although genetic, immune, metabolic susceptibility and other background investigations have been used in the study of PIH [5], the specific pathogenesis remains unclear.…”