Experimental Production of Ectopic Bone

Connor, Jerome

doi:10.1007/978-1-4471-1343-0_7

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1990

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“…Cette tenotomie/t midistance entre l'insertion calcaneenne et la masse musculaire a pour effet la formation d'ossifications darts les moignons tendineux ou musculotendineux de faqon pratiquement constante au delai de cinq mois [4,6,9,35]. Cette technique a dejfi ete utilisee, en particulier pour l'etude de l'effet des diphosphonates [28] et de l'effet de la depletion en Zinc [7] sur la formation d'ossifications heterotopiques.…”

Section: Introductionunclassified

Effet d'un inhibiteur calcique, le v�rapamil, sur le d�veloppement des ossifications h�t�rotopiques

Duriez

Flautre

Blary

et al. 1990

International Orthopaedics

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After division of the tendo achilles in rats heterotopic bone forms in the muscle and in the tendon stumps. Tenotomy was performed in 26 male rats. Thirteen received Verapamil (36 mm/Kg) for six days per week for five months, and the remainder were not given this drug. The onset of heterotopic ossification was monitored by monthly x-rays. After five months the animals were killed and the sectioned tendons examined microscopically. The radiographs had shown that the amount of ossification was less in rats treated with Verapamil. This was confirmed at microscopy, but examination of the sections under polarised light showed that the ratio of lamellar to woven bone was the same in the two groups. Verapamil appeared to reduce the amount of heterotopic bone formation but did not influence the substitution of woven by lamellar bone.

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