Experimental Protein-Calorie Deficiency

Platt, B. S.; Heard, C. R. C.; Stewart, R. J. C.

doi:10.1016/b978-1-4832-3210-2.50018-2

Cited by 55 publications

(21 citation statements)

References 114 publications

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“…This discrepancy between the oral and intravenous glucose tolerance test in malnourished animals has been quoted as evidence for diminished glucose absorption in malnutrition by Platt, Heard & Stewart (1964). In the present study, however, glucose disappearance from the gut lumen was greater in the 4% proteinfed rats than in the 20% protein-fed controls.…”

Section: Glucose Tolerancecontrasting

confidence: 79%

Glucose Tolerance and Insulin Release in Malnourished Rats

Weinkove

Pimstone

1976

Clinical Science

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1. Young Wistar rats were used as an experimental model to determine the effects of protein-energy malnutrition on glucose tolerance and insulin release. 2. Malnourished rats presented some of the features commonly found in human protein-energy malnutrition, such as failure to gain weight, hypoalbuminaemia, fatty infiltration of the liver and intolerance of oral and intravenous glucose loads. 3. The rate of disappearance of glucose from the gut lumen was greater in the malnourished rats but there was no significant difference in portal blood glucose concentration between normal and malnourished rats 5 and 10 min after an oral glucose load. 4. Insulin resistance was not thought to be the cause of the glucose intolerance in the malnourished animals since these rats had a low fasting plasma insulin concentration with a normal fasting blood glucose concentration and no impairment in their hypoglycaemic response to exogenous insulin administration. Furthermore, fasting malnourished rats were unable to correct the insulin-induced hypoglycaemia despite high concentrations of hepatic glycogen. 5. Malnourished rats had lower peak plasma insulin concentrations than normal control animals after provocation with oral and intravenous glucose, intravenous tolbutamide and intravenous glucose plus aminophyllin. This was not due to a reduction in the insulin content of the pancreas or potassium deficiency. Healthy weanling rats, like the older malnourished rats, had a diminished insulin response to intravenous glucose and intravenous tolbutamide. However, their insulin response to stimulation with intravenous glucose plus aminophyllin far exceeded that of the malnourished rats. Thus the impairment of insulin release demonstrated in the malnourished rats cannot be ascribed to a 'functional immaturity' of the pancreas.

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Section: Glucose Tolerancecontrasting

confidence: 79%

Glucose Tolerance and Insulin Release in Malnourished Rats

Weinkove

Pimstone

1976

Clinical Science

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“…Slower development of spontaneous activity and exploratory behaviors, as evidenced by the LL group and to a lesser extent by the SL group, has previously been observed (FraGkovi, 1968;Simonson, Yu, Anilane, Sherwin, & Chow, 1967;Simonson, Sherwin, Anilane, Yu, & Chow, 1969). Also, the LL pups showed a peculiar stiff-legged "hobble-skirt" gait and buckling movements of the hind-quarters attributable to possible abnormalities in bone structure (Platt, Heard, & Stewart, 1964).…”

Section: Behavioral Development Of the Offspringmentioning

confidence: 84%

The effects of prenatal and postnatal protein malnutrition on physical and motor development of the rat

Sykes

Cheyne

1976

Developmental Psychobiology

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The effects of protein malnutrition in the early stages of mammalian life have been found to be pervasive and frequently very persistent. We conducted this experiment to investigate the relative effects of protein deficiency during prenatal and/or postnatal (preweaning) stages of development in order to evaluate the effects of the timing of protein malnutrition and its duration and found significant deficits on a variety of measures of physical and motor development. Animals maintained on low protein diets both prenatally and postnatally showed the greatest developmental deficits whereas animals maintained on low protein diets either prenatally or postnatally were developmentally intermediate relative to animals maintained on normal diets.

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“…In Egypt Protein Caloric Malnutrition represents the major pediatric public health problem. Experimentally protein caloric deficiency can induce structural (2,3,4,5,6) and functional changes in the brain (7,8). In human beings kwashiorkor is associated with profound apathy and irritability (9,10) suggesting disturbed cerebral functions (11) which are expected to be associated with changes in the electric activity of the brain.…”

Section: Inthoductionmentioning

confidence: 98%