The Standard Model of particle physics predicts the existence of quantum tunnelling processes across topological inequivalent vacua, known as Instantons. In the electroweak sector, instantons provide a source of baryon asymmetry within the Standard Model. In Quantum Chromodynamics they are linked to chiral symmetry breaking and confinement. The direct experimental observation of Instanton-induced processes would therefore be a breakthrough in modern particle physics. Recently, new calculations for QCD Instanton processes in proton-proton collisions became public, suggesting sizable cross sections as well as promising experimental signatures at the LHC. In this work, we study possible analysis strategies to discover QCD Instanton induced processes at the LHC and derive a first limit based on existing Minimum Bias data.