2010
DOI: 10.1177/104063871002200411
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Experimental Rayless Goldenrod (Isocoma pluriflora) Toxicosis in Goats

Abstract: Abstract. Rayless goldenrod (Isocoma pluriflora) sporadically poisons livestock in the southwestern United States. Similarities with white snakeroot (Ageratina altissima) poisoning and nearly identical chemical analyses led early researchers to conclude that tremetol, a mixture of benzofuran ketones, is the rayless goldenrod toxin. The toxicity of these ketone toxins have not been fully characterized nor are the pathogenesis and sequelae of poisoning completely understood. The objective of the current study wa… Show more

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Cited by 17 publications
(16 citation statements)
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“…Conversely the tongue, masseter, retro-ocular, cricothyroideus and longissimus dorsi were relatively unaffected. This distribution is similar to those reported in goats dosed with rayless goldenrod (Stegelmeier et al, 2010). However, character and duration of the lesions in this study was different.…”
Section: Discussionsupporting
confidence: 87%
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“…Conversely the tongue, masseter, retro-ocular, cricothyroideus and longissimus dorsi were relatively unaffected. This distribution is similar to those reported in goats dosed with rayless goldenrod (Stegelmeier et al, 2010). However, character and duration of the lesions in this study was different.…”
Section: Discussionsupporting
confidence: 87%
“…In this study there was a good association between clinical signs of poisoning, exercise intolerance, increased serum CK activity and histology scores (Table 4). This same association was previously observed in goats poisoned with rayless goldenrod (Stegelmeier et al, 2010;Davis et al, 2013b). In future studies exercise intolerance and serum chemistry changes can be used to diagnose and monitor poisoning to better study disease progression and resolution.…”
Section: Discussionsupporting
confidence: 78%
See 1 more Smart Citation
“…16,17 The concentrations of these compounds have been measured in toxicity studies in which goats were dosed with dried white snakeroot and dried rayless goldenrod. 18 The objectives of this study were to determine the concentrations of tremetone (1), dehydrotremetone (2), and structurally similar compounds in white snakeroot and rayless goldenrod before and after various drying methods and to determine the best approach to dry plant material for future chemotaxonomic studies and animal dosing studies. We also evaluated the stability of tremetone (1) and the effect of dried white snakeroot and rayless goldenrod on goats.…”
Section: ■ Introductionmentioning
confidence: 99%
“…Much of the land in these regions is used for grazing livestock. Isocoma pluriflora , which grows in Arizona, New Mexico, West Texas, and Northern Mexico, is poisonous to livestock, causing a disease called trembles, milksickness, or alkali disease. Recently, goats and horses have been poisoned with I. pluriflora in controlled dosing studies. Trembles is manifest in livestock as depression, reluctance to eat, inactivity, rapid breathing, elevated heart rate, and muscle tremors, especially after exercise or activity. Poisoned animals often exhibit a stiff gait and stand in an altered, arched back position. , …”
Section: Introductionmentioning
confidence: 99%