Experimental Reclamping of Free-Flap Pedicles: The Effect of Prolonged Stasis on the Anastomoses and Clamp Sites

Pottie, R; Dj, Rossouw; Bj, Zeeman; Lamont, Austin

doi:10.1097/00006534-198705000-00019

Cited by 4 publications

(1 citation statement)

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“…Damage to the vessels can occur after a short application time. 19 With ischemic times of many hours, there may be irreversible endothelial damage. This may serve as a nidus for early thrombosis formation.…”

Section: Discussionmentioning

confidence: 99%

Effect of clamp versus anastomotic-induced ischemia on critical ischemic time and survival of rat epigastric fasciocutaneous flap

et al. 1999

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Section: Discussionmentioning

confidence: 99%

Effect of clamp versus anastomotic-induced ischemia on critical ischemic time and survival of rat epigastric fasciocutaneous flap

et al. 1999

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Influence of topical heparin on stasis‐induced thrombosis of microvascular anastomoses

Cooley

Gould

1992

Microsurgery

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An experiment was done to determine whether topical heparin and the association of anastomoses with dependent tissue (free flaps) exert any influences on stasis-induced microvascular thrombosis. Rat femoral vessel anastomoses with or without free flap construction were used in a total of 50 male Sprague-Dawley rats. Saline either with or without heparin was used for intralumenal irrigation during the anastomosis. Following anastomotic repair, the femoral vessels were reclamped, inducing stasis for either 2 or 4 hr. Our results showed that static blood had little adverse effect on thrombosis at the arterial anastomosis when reclamped for up to 4 hr in both standard and flap-associated anastomoses. Topical heparin significantly reduced the incidence of stasis-induced thrombosis of venous anastomoses. The venous patency rates in standard anastomoses were lower than those in flap-associated anastomoses after both 2 and 4 hr of stasis. From these results, we conclude the following. 1) Arteries may be reclamped for up to 4 hr without detriment despite static blood being in contact with the anastomotic site. 2) Topical heparin may be helpful in increasing the patency rate of venous anastomoses after a period of blood stasis. 3) Free flap construction may play a role in decreasing stasis-induced microvascular thrombosis.

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Uw solution as an experimental microvascular skin flap perfusate

1993

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UW solution has been found to be an effective organ perfusate for transplantation. Initial studies in experimental pedicle skin flaps have also demonstrated its unique effectiveness in prolonged ischemia. To understand better the limits of its preservation properties without the influence of endothelial clamp damage, we have undertaken to study the properties of UW solution in experimental microvascular free flaps. Control, lactated Ringer's, and UW solutions were utilized in pedicle and microvascular free flaps in Sprague-Dawley rats over varying periods of ischemia. UW solution demonstrated a clear superiority over all other solutions in both flap models. In addition there also was a significant prolongation of critical ischemia time in UW-treated free flaps compared to pedicle flaps.

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Experimental Reclamping of Free-Flap Pedicles: The Effect of Prolonged Stasis on the Anastomoses and Clamp Sites

Cited by 4 publications

References 0 publications

Effect of clamp versus anastomotic-induced ischemia on critical ischemic time and survival of rat epigastric fasciocutaneous flap

Effect of clamp versus anastomotic-induced ischemia on critical ischemic time and survival of rat epigastric fasciocutaneous flap

Influence of topical heparin on stasis‐induced thrombosis of microvascular anastomoses

Uw solution as an experimental microvascular skin flap perfusate

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