Experimental regeneration in peripheral nerves and the spinal cord in laboratory animals exposed to a pulsed electromagnetic field

Wilson, David H.; Jagadeesh, P

doi:10.1038/sc.1976.2

Cited by 70 publications

(39 citation statements)

References 4 publications

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“…Wilson and Jagadeesh [1976] were the first to demonstrate that PMF exposure can enhance nerve regeneration in a rat model, and this finding was later corroborated by others. In vitro, PMFs enhanced outgrowth of neurites from cultured spinal cord and peripheral ganglia [Sisken et al, 1984[Sisken et al, , 1988.…”

Section: Discussionmentioning

confidence: 57%

Effect of weak, interrupted sinusoidal low frequency magnetic field on neural regeneration in rats: Functional evaluation

Bervar

2005

Bioelectromagnetics

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A study of the effect of weak, interrupted sinusoidal low frequency magnetic field (ISMF) stimulation on regeneration of the rat sciatic nerve was carried out. In the experiment, 60 Wistar rats were used: 24 rats underwent unilateral sciatic nerve transection injury and immediate surgical nerve repair, 24 rats underwent unilateral sciatic nerve crush injury, and the remaining 12 rats underwent a sham surgery. Half of the animals (n = 12) with either sciatic nerve lesion were randomly chosen and exposed between a pair of Helmholtz coils for 3 weeks post-injury, 4 h/day, to an interrupted (active period to pause ratio = 1.4 s/0.8 s) sinusoidal 50 Hz magnetic field of 0.5 mT. The other half of the animals (n = 12) and six rats with sham surgery were used for two separate controls. Functional recovery was followed for 6 weeks for the crush injuries and 7(1/2) months for the transection injuries by video assisted footprint analysis in static conditions and quantified using a recently revised static sciatic index (SSI) formula. We ascertained that the magnetic field influence was weak, but certainly detectable in both injury models. The accuracy of ISMF influence detection, determined by the one-way repeated measures ANOVA test, was better for the crush injury model: F(1, 198) = 9.0144, P = .003, than for the transection injury model: F(1, 198) = 6.4826, P = .012. The Student-Newman-Keuls range test for each response day yielded significant differences (P < .05) between the exposed and control groups early in the beginning of functional recovery and later on from the points adjacent to the beginning of the plateau, or 95% of functional recovery, and the end of observation. These differences probably reflect the ISMF systemic effect on the neuron cell bodies and increased and more efficient reinnervation of the periphery.

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Section: Discussionmentioning

confidence: 57%

Effect of weak, interrupted sinusoidal low frequency magnetic field on neural regeneration in rats: Functional evaluation

Bervar

2005

Bioelectromagnetics

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“…Thus, the tissue is stimulated by the electrical current transferred from the generating device to the brain via magnetic fields. There are several recently published reviews and books describing application of rTMS in several disorders of the central nervous system (CNS) (Pascual-Leone, et al, 2002;Walsh and Pascual-Leone, 2003), although reports describing the application of this type of stimulation directly to the site of the spinal cord/nerve injury are rare (Wilson and Jagadeesh, 1976;Orgel et al, 1984). Cranial application of rTMS was reported to significantly improve locomotor recovery after spinal cord lesions in rats (Poirrier et al, 2004) and humans (Belci et al, 2004).…”

mentioning

confidence: 99%

Combined Effects of Acrobatic Exercise and Magnetic Stimulation on the Functional Recovery after Spinal Cord Lesions

Ahmed

Wieraszko²

2008

Journal of Neurotrauma

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The objective of the study was to determine whether physical exercise combined with epidural spinal cord magnetic stimulation could improve recovery after injury of the spinal cord. Spinal cord lesioning in mice resulted in reduced locomotor function and negatively affected the muscle strength tested in vitro. Acrobatic exercise attenuated the behavioral effects of spinal cord injury. The exposure to magnetic fields facilitated further this improvement. The progress in behavioral recovery was correlated with reduced muscle degeneration and enhanced muscle contraction. The acrobatic exercise combined with stimulation with magnetic fields significantly facilitates behavioral recovery and muscle physiology in mice following spinal cord injury.

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“…I have previously reported on the use of pulsed electromagnetic field therapy to accelerate the regeneration of peripheral nerves and to promote the healing of experimental cordotomies (Wilson & Jagadeesh 1976). The value of this treatment in stimulating peripheral nerve healing has recently been confirmed in an independent study (Raji & Bowden 1982).…”

Section: Discussionmentioning

confidence: 97%

Peripheral nerve implants in the spinal cord in experimental animals

Wilson

1984

Spinal Cord

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SUIDIDary. This paper challenges the concept of 'spinal cord autotomy' as an essential process which will prevent the penetration of spinal cord fibres into a peripheral nerve implant.It proposes that mechanical distraction between the graft and the cord is the main reason why spinal cord fibres fail to traverse a graft. Clinical, neurophysiological and histological evidence is presented to show that embedding an autogenous peripheral nerve implant into a trough in the dorsal half of the cord is effective in restoring continuity in some of the long fibre tracts. Reference is made to other recent work which supports these observations. Possible methods of enhancing the number of fibres which traverse the graft are discussed and an attempt is made to anticipate the possible results of the clinical application of this technique in spinal cord injury patients.

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Experimental regeneration in peripheral nerves and the spinal cord in laboratory animals exposed to a pulsed electromagnetic field

Cited by 70 publications

References 4 publications

Effect of weak, interrupted sinusoidal low frequency magnetic field on neural regeneration in rats: Functional evaluation

Effect of weak, interrupted sinusoidal low frequency magnetic field on neural regeneration in rats: Functional evaluation

Combined Effects of Acrobatic Exercise and Magnetic Stimulation on the Functional Recovery after Spinal Cord Lesions

Peripheral nerve implants in the spinal cord in experimental animals

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