2020
DOI: 10.1016/j.knee.2019.12.012
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Experimental reproduction of periprosthetic joint infection: Developing a representative animal model

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Cited by 6 publications
(21 citation statements)
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“…All animals had their proximal tibial metaphysis replaced by a stainless steel insert designed by 3D printing according to the technique described in another study [19]. After implantation and closure of the arthrotomy, 1 mL of 10 5 CFU from the methicillin-sensitive Staphylococcus aureus strain ATCC® 29,213™ was inoculated by intraarticular injection [20]. One week after the inoculation, the animals were re-anaesthetised to carry out the first stage of prosthetic replacement, intra-operative samples were taken to verify the presence of infection, the stainless steel insert was removed, and a cement spacer was fitted.…”
Section: Animals and Surgical Proceduresmentioning
confidence: 99%
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“…All animals had their proximal tibial metaphysis replaced by a stainless steel insert designed by 3D printing according to the technique described in another study [19]. After implantation and closure of the arthrotomy, 1 mL of 10 5 CFU from the methicillin-sensitive Staphylococcus aureus strain ATCC® 29,213™ was inoculated by intraarticular injection [20]. One week after the inoculation, the animals were re-anaesthetised to carry out the first stage of prosthetic replacement, intra-operative samples were taken to verify the presence of infection, the stainless steel insert was removed, and a cement spacer was fitted.…”
Section: Animals and Surgical Proceduresmentioning
confidence: 99%
“…1B). The diagnostic criteria for infection are summarised in Table 1 [20]. The evolution of the inflammatory parameters was defined according to variations in ESR, leukocyte count, platelet count, and percentage of serum lymphocytes.…”
Section: Analytical Determinationsmentioning
confidence: 99%
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“…An excessively large inoculum can cause sepsis and death while an insufficient inoculum will quickly be cleared. 34,163,164 The duration of time following the inoculation of the pathogen in which the infection is established in the model must also be considered since this is dependent upon the species used in the model and differs from clinical presentation. 31 Additionally, the virulence of the bacterial strain used in the model and the culture conditions (i.e., log phase versus stationary phase growth) impact the concentration of the inoculum required to establish an infection.…”
Section: Considerations In Establishing Clinically Relevant Preclinic...mentioning
confidence: 99%
“…32,33 Technological advancements (e.g., 3Dprinting, bacterial genomic sequencing, etc. 33,34 ) have enabled the development of more clinically relevant and reproducible in vivo models that may facilitate and improve understanding of the development and treatment of implant-associated infections moving forward. Furthermore, advances in realtime in vivo imaging modalities (e.g., positron emission tomography (PET), fluorescence) and radioactive tracers and probes offer the potential to monitor the efficacy of antimicrobial orthopedic materials and progression of infection and inflammation noninvasively.…”
Section: Introductionmentioning
confidence: 99%