Titanium alloy is widely used in aerospace and other fields because of its high strength, low density, good corrosion resistance and high temperature resistance. In high speed milling titanium alloy, due to the poor thermal conductivity of titanium alloy and the change of cutting mechanism caused by high speed machining, it is great significance to study the cutting temperature in high speed milling process. Based on the moving heat source method, the temperature field model of milling workpiece considering spiral edge was established, and the influence of milling speed on workpiece temperature was analyzed through the change of heat flux during milling. The thermocouple wireless temperature acquisition system was used to record the change of workpiece surface temperature in the milling process, and MATLAB was used for the simulation analysis of milling temperature. The results showed that the cutting speed mainly affected the heat flux of the heat source, thereby caused temperature rise of the workpiece. The peak temperature and response speed of measuring point are different in varying spindle speeds and measuring point positions.