Experimental results of full scattering profile from finger tissue-like phantom

Feder, Idit; Wróbel, Maciej S.; Duadi, Hamootal; Jędrzejewska‐Szczerska, Małgorzata; Fixler, Dror

doi:10.1364/boe.7.004695

Cited by 20 publications

(18 citation statements)

References 29 publications

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“…The experimental setup for measuring the FSP is based on a photodiode detector placed on a rotation stage adjacent to an irradiated tissue in order to measure the reemitted light , as shown in Figure . The setup includes a He‐Ne gas laser (Thorlabs, Newton, Massachusetts) with an excitation wavelength of λ = 632.8 nm and maximum power of 8 mW.…”

Section: Methodsmentioning

confidence: 99%

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Near‐infrared human finger measurements based on self‐calibration point: Simulation and in vivo experiments

Duadi

Feder

Fixler

2017

Journal of Biophotonics

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Near-infrared light allows measuring tissue oxygenation. These measurements relay on oxygenation-dependent absorption spectral changes. However, the tissue scattering, which is also spectral dependent, introduces an intrinsic error. Most methods focus on the volume reflectance from a semi-infinite sample. We have proposed examining the full scattering profile (FSP), which is the angular intensity distribution. A point was found, that is, the iso-path length (IPL) point, which is not dependent on the tissue scattering, and can serve for self-calibration. This point is geometric dependent, hence in cylindrical tissues depends solely on the diameter. In this work, we examine an elliptic tissue cross section via Monte Carlo simulation. We have found that the IPL point of an elliptic tissue cross section is indifferent to the input illumination orientation. Furthermore, the IPL point is the same as in a circular cross section with a radius equal to the effective ellipse radius. This is despite the fact that the FSPs of the circular and elliptical cross sections are different. Hence, changing the orientation of the input illumination reveals the IPL point. In order to demonstrate this experimentally, the FSPs of a few female fingers were measured at 2 perpendicular orientations. The crossing point between these FSPs was found equivalent to the IPL point of a cylindrical phantom with a radius similar to the effective radius. The findings of this work will allow accurate pulse oximetry assessment of blood saturation.

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Section: Methodsmentioning

confidence: 99%

“…This point is geometric dependent, hence in cylindrical tissues it depends solely on the tissue diameter . We have previously found this IPL point to be linearly dependent on the tissue diameter both via Monte Carlo (MC) simulation and while measuring different types of tissue mimicking phantoms .…”

Section: Introductionmentioning

confidence: 99%

Near‐infrared human finger measurements based on self‐calibration point: Simulation and in vivo experiments

Duadi

Feder

Fixler

2017

Journal of Biophotonics

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“…Optical phantoms are also very durable. Unlike real tissues, they are resistant to degradation and therefore preserve their optical parameters-which is beneficial during the long-term examination of the relationship between light and matter [12,13].…”

Section: Introductionmentioning

confidence: 99%

A Measurement System for Quasi-Spectral Determination of Absorption and Scattering Parameters of Veterinary Tissue Phantoms

et al. 2019

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This paper describes the construction of a system for the quasi-spectral determination of absorption and scattering parameters of animal tissue phantoms. Several tissue phantoms, including one reference and two modified for examination, were prepared from polydimethylsiloxane (PDMS). The phantoms were measured using a system based on an integrating sphere and the light sources of wavelengths commonly used for the treatment of various diseases in veterinary medicine, including 635 nm (red), 532 nm (green) and 447 nm (blue). The obtained results are consistent with data provided in reference sources and can also be approximated for the entire spectral range of visible radiation (380–780 nm). The developed system is suitable for further measurements of phantoms, which can be adapted to imitate different tissues.

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“…In the experimental measurements we used previously developed nanoparticles-free optical tissue phantoms, consisting of polydimethylosiloxane polymer and glycerol fabricated at Gdańsk University of Technology, Poland. The details of their fabrication and optical properties can be found in previous publications [15,16].…”

Section: Introductionmentioning

confidence: 99%

Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation

et al. 2017

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In brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and other small molecules found in plasma. The CSF acts as a cushion behind the skull, providing basic mechanical as well as immunological protection to the brain. Disturbances of the CSF circulation have been linked to several brain related medical disorders, such as dementia. Our goal is to develop an in vivo method for the non-invasive measurement of cerebral blood flow and CSF circulation by exploiting optical and capacitive sensing techniques simultaneously. We introduce a prototype of a wearable probe that is aimed to be used for long-term brain monitoring purposes, especially focusing on studies of the glymphatic system. In this method, changes in cerebral blood flow, particularly oxy-and deoxyhaemoglobin, are measured simultaneously and analysed with the response gathered by the capacitive sensor in order to distinct the dynamics of the CSF circulation behind the skull. Presented prototype probe is tested by measuring liquid flows inside phantoms mimicking the CSF circulation.

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Experimental results of full scattering profile from finger tissue-like phantom

Cited by 20 publications

References 29 publications

Near‐infrared human finger measurements based on self‐calibration point: Simulation and in vivo experiments

Near‐infrared human finger measurements based on self‐calibration point: Simulation and in vivo experiments

A Measurement System for Quasi-Spectral Determination of Absorption and Scattering Parameters of Veterinary Tissue Phantoms

Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation

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