Experimental Retinal Detachment

Pederson, Jonathan E.; Cantrill, Herbert L.

doi:10.1001/archopht.1984.01040030114048

Cited by 50 publications

(3 citation statements)

References 18 publications

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“…Flow through the corneal and iridial routes has been shown to be negligible (Bill 1977). Flow through the retinal route is generated by the pumping capacity of the retinal pigment epithelium, but is considered to be small as long as the retina remains attached (Pederson and Cantrill 1984). This review will focus on the flow exiting the posterior aspect of the uveal meshwork, passing through the ciliary muscle, and entering the suprachoroidal space.…”

Section: Historical Basis Of Unconventional Outflowmentioning

confidence: 99%

Unconventional aqueous humor outflow: A review

Johnson

McLaren

Overby

2017

Experimental Eye Research

169

120

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Aqueous humor flows out of the eye primarily through the conventional outflow pathway that includes the trabecular meshwork and Schlemm's canal. However, a fraction of aqueous humor passes through an alternative or ‘unconventional’ route that includes the ciliary muscle, supraciliary and suprachoroidal spaces. From there, unconventional outflow may drain through two pathways: a uveoscleral pathway where aqueous drains across the sclera to be resorbed by orbital vessels, and a uveovortex pathway where aqueous humor enters the choroid to drain through the vortex veins. We review the anatomy, physiology and pharmacology of these pathways. We also discuss methods to determine unconventional outflow rate, including direct techniques that use radioactive or fluorescent tracers recovered from tissues in the unconventional pathway and indirect methods that estimate unconventional outflow based on total outflow over a range of pressures. Indirect methods are subject to a number of assumptions and generally give poor agreement with tracer measurements. We review the variety of animal models that have been used to study conventional and unconventional outflow. The mouse appears to be a promising model because it captures several aspects of conventional and unconventional outflow dynamics common to humans, although questions remain regarding the magnitude of unconventional outflow in mice. Finally, we review future directions. There is a clear need to develop improved methods for measuring unconventional outflow in both animals and humans.

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Section: Historical Basis Of Unconventional Outflowmentioning

confidence: 99%

Unconventional aqueous humor outflow: A review

Johnson

McLaren

Overby

2017

Experimental Eye Research

169

120

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“…The main limitations of this study were that the effect of local drug metabolism, the drug binding to intraocular proteins, and the influence of the location of the site of IJ and IP have not been evaluated. Also, the phrase "diseased condition" could imply the change in retinal permeability, abnormal vitreous outflow, 14,31 or both. Disruption of retina owing to a large number of retinal diseases simultaneously alters the pattern of drug movement and its distribution inside the ocular chambers.…”

Section: Discussionmentioning

confidence: 99%

“…Disruption of retina owing to a large number of retinal diseases simultaneously alters the pattern of drug movement and its distribution inside the ocular chambers. 5,31,32 Although retinal-permeability changes are both owing to the physicochemical properties of drugs and the pathophysiologic conditions, this study assumed the retinal per-meability only as a function of the physicochemical property of the drug. The diseased condition was taken care of by the elevated vitreous outflow condition (F10).…”

Section: Discussionmentioning

confidence: 99%

Effect of Retinal Permeability, Diffusivity, and Aqueous Humor Hydrodynamics on Pharmacokinetics of Drugs in the Eye

Krishnamoorthy

Park

Augsburger

et al. 2008

Journal of Ocular Pharmacology and Therapeutics

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Thus, the combined effect of variables P, D, and F are important factors that should be considered in order to determine drug dosage. This study could be used to estimate the drug distribution and elimination for (1) wide range of physicochemical properties of drugs and (2) normal and abnormally elevated vitreous flows during the diseased condition of the eye. These results could help in obtaining essential information about the treatment protocol for targeted retinal diseases while simultaneously avoiding the toxic effects of these drugs.

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Spontaneous Resolution of Retinal Detachment Occurring After Macular Hole Surgery

Akduman¹

1998

Arch Ophthalmol

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To document the spontaneous resolution of retinal detachment developing after macular hole surgery. Methods: We identified all patients who developed a postoperative retinal detachment after undergoing macular hole surgery at Washington University School of Medicine, St Louis, Mo; the surgery was performed by one of us (L.V.D.P. or H.J.K.) between 1991 and 1996. Results: Six of 73 eyes developed a postoperative retinal detachment; the retinal detachment was inferior in all cases. Two eyes that had inferior retinal breaks underwent further surgery to repair the retinal detachment. Retinal breaks could not be identified in the other 4 eyes; the retinal detachment resolved without further surgery in all 4 of these eyes. Conclusion: The recognition that retinal detachment occurring after macular hole surgery can resolve without additional surgery may result in the avoidance of further surgical intervention in some eyes.

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Experimental Retinal Detachment

Cited by 50 publications

References 18 publications

Unconventional aqueous humor outflow: A review

Unconventional aqueous humor outflow: A review

Effect of Retinal Permeability, Diffusivity, and Aqueous Humor Hydrodynamics on Pharmacokinetics of Drugs in the Eye

Spontaneous Resolution of Retinal Detachment Occurring After Macular Hole Surgery

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