Experimental Retinal Detachment

deGuillebon, Henri

doi:10.1001/archopht.1972.01000020547012

Cited by 42 publications

(5 citation statements)

References 5 publications

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“…Whether the shear stress generated by aqueous sloshing can elevate retinal tears and allow fluid into the subretinal space is a lengthy debated issue. 18 Retinal adhesion strength has been estimated across a broad range (4–266 Pa), 27–29 and it is known to temporarily decline after retinopexy 30 to less than 4 Pa or approximately 50% of the initial strength after 8 hours and then increase within 24 hours 31 ; such values are lower than those calculated in our model and suggest this mechanism is conceivable. Although it is simplistic to believe that this is the only or main factor responsible for retinal redetachment, many activities resulted in shear stress exceeding this value (Figure 7).…”

Section: Discussioncontrasting

confidence: 57%

Do Daily Activities Affect Gas Tamponade‒retina Contact After Pars Plana Vitrectomy?

Rossi

Badas

DEng

et al. 2023

Retina

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Purpose: To calculate the retinal surface alternatively in contact with gas and aqueous because of fluid sloshing during daily activities such as ocular saccade, turning the head, standing up, and being a passenger of a braking car.Methods: Fluid dynamics of aqueous and gas tamponade was reproduced using computational methods using the OpenFOAM open-source library. The double-fluid dynamics was simulated by the volume of fluid method and setting the contact angle at the aqueous-gas-retina interface.Results: Sloshing increased the retinal surface in contact with aqueous by 13% to 16% regardless of fill rate and standing up determined the largest area of wet retina, followed by car braking, head rotation, and ocular saccade (P , 0.001). All activities except the ocular saccade determined a significant increase in the surface of retina in contact with the aqueous (P , 0.005). Car braking induced the highest shear stress (6.06 Pa); standing up determined the highest specific impulse and saccade the lowest.Conclusion: Daily activities instantaneously reduce the amount of retina consistently in contact with gas tamponade and increase shear stress giving aqueous a potential access to the subretinal space regardless of patients' compliance.

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Section: Discussioncontrasting

confidence: 57%

Do Daily Activities Affect Gas Tamponade‒retina Contact After Pars Plana Vitrectomy?

Rossi

Badas

DEng

et al. 2023

Retina

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“…As viscoelastic materials, ocular tissues demonstrate a rate-dependent response to deformation; thus, highervelocity projectiles generate greater levels of stress in the involved tissues. [2][3][4] BB guns, the most common culprits in chorioretinitis sclopetaria, can reach firing speeds in the 350 to 400 miles per hour range. 5 In comparison, our patient's chorioretinal trauma was mediated by a commercial-grade pressure washer, a machine with the ability to output water at speeds in the 400 to 500 miles per hour range.…”

Section: Discussionmentioning

confidence: 99%

Chorioretinitis Sclopetaria and Orbital Emphysema Caused by a High-Velocity Liquid Missile

Kamboj

Hwang

Kulenkamp

et al. 2023

RETINAL Cases &Amp; Brief Reports

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“…Several studies have quantitatively measured adhesion between the neurosensory layer and retina pigment epithelium (RPE) (Zauberman and Berman, 1969 ; Lincoff et al, 1970 ; DeGuillebon et al, 1971 , 1972 ; DeGuillebon and Zauberman, 1972 ; Zauberman, 1972 ; Zauberman and DeGuillebon, 1972 ; Zauberman et al, 1972 ; Owczarek et al, 1975 ; Kain, 1984 ). Similar to our results, these studies report significantly greater adhesion in the equator compared to the posterior pole.…”

Section: Discussionmentioning

confidence: 99%

“…The retina was scored on both sides of the tab as well as one end of the peel region to ensure a clean rectangular peel shape throughout the duration of the test. The tab was raised at a quasistatic rate of 0.02 mm/s in accordance with other previous peel test literature (DeGuillebon and Zauberman, 1972 ; Zauberman and DeGuillebon, 1972 ; ASTM, 2016 ). The eye holder rotated simultaneously using a pulley system connected to the Instron crosshead.…”

Section: Methodsmentioning

confidence: 98%

“…No studies to date have directly measured adhesive forces at the vitreoretinal interface, but there are several studies that quantified retinal separation at the pigment epithelium (RPE). The earliest series of studies were by Zauberman and deGuillebon (Zauberman and Berman, 1969 ; DeGuillebon et al, 1971 ; DeGuillebon and Zauberman, 1972 ; Zauberman, 1972 ) in monkey, cat, and rabbit eyes. Both groups excised rectangular specimens from the eye containing retina, choroid, and sclera.…”

Section: Introductionmentioning

confidence: 99%

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Changes in Vitreoretinal Adhesion With Age and Region in Human and Sheep Eyes

Creveling

Colter

Coats

2018

Front. Bioeng. Biotechnol.

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While several studies have qualitatively investigated age- and region-dependent adhesion between the vitreous and retina, no studies have directly measured the vitreoretinal strength of adhesion. In this study, we developed a rotational peel device and associated methodology to measure the maximum and steady-state peel forces between the vitreous and the retina. Vitreoretinal adhesion in the equator and posterior pole were measured in human eyes from donors ranging 30 to 79 years of age, and in sheep eyes from premature, neonatal, young lamb, and young adult sheep. In human eyes, maximum peel force in the equator (7.24 ± 4.13 mN) was greater than in the posterior pole (4.08 ± 2.03 mN). This trend was especially evident for younger eyes from donors 30 to 39 years of age. After 60 years of age, there was a significant decrease in the maximum equatorial (4.69 ± 2.52 mN, p = 0.016) and posterior pole adhesion (2.95 ± 1.25 mN, p = 0.037). In immature sheep eyes, maximum adhesion was 7.60 ± 3.06 mN, and did not significantly differ between the equator and posterior pole until young adulthood. At this age, the maximum adhesion in the equator nearly doubled (16.67 ± 7.45 mN) that of the posterior pole, similar to the young adult human eyes. Light microscopy images suggest more disruption of the inner limiting membrane (ILM) in immature sheep eyes compared to adult sheep eyes. Interestingly, in human eyes, ILM disruption was significantly greater in the posterior pole (p < 0.05) and in people over 60 years of age (p < 0.02). These findings supplement the current discussion surrounding age-related posterior vitreous detachment, and the risk factors and physiological progressions associated with this condition. In addition, these data further our understanding of the biomechanical mechanisms of vitreoretinal adhesion, and can be used to develop age- appropriate computational models simulating retinal detachment, hemorrhaging, or retinal trauma.

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Experimental Retinal Detachment

Cited by 42 publications

References 5 publications

Do Daily Activities Affect Gas Tamponade‒retina Contact After Pars Plana Vitrectomy?

Do Daily Activities Affect Gas Tamponade‒retina Contact After Pars Plana Vitrectomy?

Chorioretinitis Sclopetaria and Orbital Emphysema Caused by a High-Velocity Liquid Missile

Changes in Vitreoretinal Adhesion With Age and Region in Human and Sheep Eyes

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