Experimental Retinal Detachment

An Experimental Model of Rhegmatogenous Retinal Detachment: Surgical Results and Glial Cell Response

“…This may explain a wide variation in the reported anatomic success, ranging from 0% to 100%. 3,6,8,20,22,25,26,32,33,37,38 This study modified existing models of RD to simulate the usual clinical presentation of human RRD. All RDs persisted for the duration of the study and many increased in size.…”

“…44 Posterior Vitreous Detachment and Lens Status. Many models of RD attempt to liquefy or remove some of the vitreous gel through chemical 5,10,32,33,37 or mechanical means, 8,11,12,20,22,25,45 but few 14 perform a complete vitrectomy or create a PVD. 4 In the pig it was possible to create a PVD, and this may have contributed to a high anatomic success rate.…”

“…4,11,14,27 Lensectomy was not required in the pig because the lens did not usually obstruct access to the vitreous cavity. This provided a phakic model of RD and unlike many studies, 20,29,32,46 animals underwent only one operation to create an RD.…”

“…6,20,[22][23][24][25][26]29 Many models of RDs remove the crystalline lens, 4,11,14,27 yet most patients with RD are have phakic eyes. 30 A variety of animal species have been selected to model human RD, including rabbit, 3,6,7,[11][12][13]20,[22][23][24][25]29,31,32 cat, 27 dog, 2,26 and primate. 8,33 Individually, each of these species have important differences from human eyes in terms of either the size of the globe and crystalline lens, scleral rigidity, vitreous turgor, retinal circulation, photoreceptor type and distribution, or features such as a tapetum cellulosum.…”

Management of Peripheral Retinal Breaks

“…Thus, a hole with an operculum results. Although Cockerham and Freeman [8] are of the opinion that retinal breaks with opercula may not require prophylasis since vitreous traction has been released, this contradicts the experimental [17,18] and clinical conclusions of the role played by the vitreous traction in the mechanism of formation of retinal breaks and its significance in the subsequent progress to retinal detachment [19][20][21]. Thus, we feel that a peripheral retinal break with an operculum indicates prophylactic treatment.…”